Hydrogen Tunneling in Carboxylic and Amino Acids

• Antragsteller: Professor Dr. Peter R. Schreiner
• Fachliche Zuordnung: Organische Molekülchemie - Synthese, Charakterisierung
• Förderung: Förderung von 2011 bis 2015
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 202685893

The proposed research intends to unearth the important role of hydrogen tunneling in the dynamics of organic compounds of biological significance, namely, the α-keto carboxylic (1) and α-amino acid (2) paradigms. For this purpose, an international collaboration will be built that weds matrix isolation experiments in Germany with high-level ab initio theory in the United States. Our combined experimental and theoretical work will focus on tunneling phenomena in the rotational isomerizations of numerous molecules of type 1 [with R = H, CH3, aryl, cyclopropyl, (CH2)nCOOH] and 2 (beginning with Gly, Ala, Phe, Cys). The results could have profound implications for understanding kinetic stability and conformational dynamics in such systems.

• DFG-Verfahren: Sachbeihilfen
• Internationaler Bezug: USA
• Beteiligte Person: Professor Wesley D. Allen