Project Details
Projekt
Deciphering mechanisms of kindlin3 and talin1-mediated integrin activation and signaling in hematopoietic cells (A01)
Subject Area
Cell Biology
Term
from 2011 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 165054336
Leukocyte trafficking depends on talin1- and kindlin3-mediated control of integrin activity. In the proposed project we aim to investigate the role of leupaxin, a new kindlin3 interactor, in adhesion structure formation, signaling and leukocyte trafficking in vitro and in vivo. We further aim to study the molecular mechanisms of talin1 recruitment to the plasma membrane by analyzing mouse mutants and genetically engineered cells carrying mutations in talin1, which abolish different putative pathways of talin1 membrane targeting.
DFG Programme
Collaborative Research Centres
Applicant Institution
Ludwig-Maximilians-Universität München
Project Head
Privatdozent Dr. Markus Moser
