Entschlüsselung der Rolle von H2O2 aus veschiedenen Zellorganellen und Zelltypen in der Signaltransduktion
Zusammenfassung der Projektergebnisse
In summary, the transcriptional dynamics of the TFs after H2O2 production was assessed and the analysis of subcellular localization and potential H2O2- triggered mobility of selected TFs was initiated. We are now continuing the proposed activities of the proposal to reach the aims and produce publications. Follow-up analysis of the biological function of At3g02840 should still be performed. We showed induced resistance of GO5 against C. higginsianum, which is completely dependent on WRKY33. We now hypothesize that indole carbonyl nitriles might play a role in defense against C. higginsianum and will work further in this direction. We found that detoxification of RCS involves at least three subcellular compartments and depends on a specific GLXI isoform during germination. Furthermore, our work allow to propose that GLXI;like proteins are not active GLX. Further work aiming to understand the molecular and biological function of GLXI-like proteins is in progress. We wrote a review article on our work on damage-control systems for small molecules.
Projektbezogene Publikationen (Auswahl)
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(2015) Activation of cyclic electron flow by hydrogen peroxide in vivo. PNAS 112, 5539-5544
Strand DD, Livingston AK, Satoh-Cruz M, Froehlich JE, Maurino VG, Kramer DM
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(2017) Defense against reactive carbonyl species involves at least three subcellular compartments where individual components of the system respond to the cellular sugar status. Plant Cell 29, 3234-3254
Schmitz J, Dittmar IC, Brockmann JD, Schmidt M, Hüdig M, Rossoni AW, Maurino VG
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(2018) Biochemical control systems for small molecule damage in plants. Plant Signal. Behav. 13(5):e1477906
Hüdig M, Schmitz J, Engqvist MKM, Maurino VG
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(2018) Dissecting the physiological function of Glyoxalase I and Glyoxalase I-like proteins. Front. Plant Sci. 9:1618
Schmitz J, Rossoni AW, Maurino VG
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Control systems for small molecule damage in plants, HHU Düsseldorf, PhD Thesis, 2018
Meike Hüdig
