KFO 146:  Cell-mediated Suppression of Auto- and Alloreactive Immune Responses

• Subject Area: Medicine
• Term: from 2006 to 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 18407128

• Final Report Year: 2016

Final Report Abstract

No abstract available

Publications

• Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity. Genome Research, Vol. 19. 2009, pp. 1165-1174.
  Schmidl, C., M. Klug, T.J. Boeld, R. Andreesen, P. Hoffmann, M. Edinger, M. Rehli
  (See online at https://dx.doi.org/10.1101/gr.091470.109)
• Primary human colonic epithelial cells are transiently protected from anoikis by a Src-dependent mechanism. Biochemical and Biophysical Research Communications, Vol. 390. 2009, Issue 3, pp. 908-914.
  Hofmann C, Lippert E, Falk W, Schölmerich J, Rogler G, Obermeier F.
  (See online at https://doi.org/10.1016/j.bbrc.2009.10.075)
• Basophils support the survival of plasma cells in mice. Journal of Immunology, Vol. 185. 2010, Issue 12, pp. 7180-7185.
  Rodriguez Gomez, M., Talke, Y., Goebel, N., Hermann, F., Reich, B., Mack, M.
  (See online at https://doi.org/10.4049/jimmunol.1002319)
• Isolation of intact genomic DNA from FOXP3-sorted human regulatory T cells for epigenetic analyses. European Journal of Immunology, Vol. 40. 2010, Issue 5, pp. 1510–1512.
  Hansmann, L., C. Schmidl, T.J. Boeld, R. Andreesen, P. Hoffmann, M. Rehli, M. Edinger.
  (See online at https://dx.doi.org/10.1002/eji.200940154)
• T-cell dependent protective effects of CpG-ODN in experimental colitis are mediated by CD11c+ dendritic cells. Gut, Vol. 59.2010, Issue 10, pp. 1347-1354.
  Hofmann C., Dunger N., Grunwald N., Hämmerling G.J., Hoffmann P., Schölmerich J., Falk W., Obermeier F.
  (See online at https://dx.doi.org/10.1136/gut.2009.193177)
• Cutting Edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients. Journal of Immunology, Vol. 187. 2011, Issue 5, pp. 2072-2078.
  Hutchinson J.A., Riquelme P., Sawitzki B., Tomiuk S., Miqueu P., Zuhayra M., Oberg H., Pascher A., Lützen U., Janssen U., Broichhausen C., Renders L., Thaiss F., Scheuermann E., Henze E., Volk H.D., Chatenoud L., Lechler R.I., Wood K.J., Kabelitz D., Schlitt H.J., Geissler E.K., Fändrich F.
  (See online at https://doi.org/10.4049/jimmunol.1100762)
• Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naive Treg. European Journal of Immunology, Vol. 41. 2011, Issue 5, pp. 1491–1498.
  Schmidl, C., L. Hansmann, R. Andreesen, M. Edinger, P. Hoffmann, M. Rehli
  (See online at https://dx.doi.org/10.1002/eji.201041067)
• Human regulatory macrophages. In: Suppression and Regulation of Immune Responses - Methods and Protocols, eds.: Maria Cristina Cuturi, Ignacio Anegon. Methods in Molecular Biology(MIMB), Vol. 677. 2011, pp. 181-192.
  Hutchinson JA, Riquelme P, Geissler EK, Fändrich F.
  (See online at https://doi.org/10.1007/978-1-60761-869-0_13)
• Studies on galactofuranose-containing glycostructures of the pathogenic mold Aspergillus fumigatus. International Journal of Medical Microbiology, Vol. 301. 2011, Issue 6, pp. 523-530.
  Heesemann L., Kotz A., Echtenacher B, Broniszewska M., Routier F., Hoffmann P., Ebel F.
  (See online at https://doi.org/10.1016/j.ijmm.2011.02.003)
• IL-33 attenuates development and perpetuation of chronic intestinal inflammation. Inflammatory Bowel Diseases, Vol. 18. 2012, Issue 10, pp. 1900–1909.
  Groβ P., Doser K., Falk W., Obermeier F., Hofmann C.
  (See online at https://doi.org/10.1002/ibd.22900)
• Novel serial positive enrichment technology enables clinical multiparameter cell sorting. PLoS One, Vol. 7. 2012, Issue 4: e35798.
  Stemberger, C., S. Dreher, C. Tschulik, C. Piossek, J. Bet, T.N. Yamamoto, M. Schiemann, M. Neuenhahn, K. Martin, M. Schlapschy, A. Skerra, T. Schmidt, M. Edinger, S.R. Riddell, L. Germeroth, D.H. Busch
  (See online at https://doi.org/10.1371/journal.pone.0035798)
• Regulatory macrophages as therapeutic targets and therapeutic agents in solid organ transplantation. Current Opinion in Organ Transplantation, Vol. 17. 2012, Issue 4, pp. 332–342.
  Broichhausen C., Riquelme P., Geissler E.K., Hutchinson J.A.
  (See online at https://doi.org/10.1097/MOT.0b013e328355a979)
• ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression. Nature Medicine, vol. 18. 2012, pp. 128–134.
  Hoetzenecker W., Echtenacher B., Guenova E., Hoetzenecker K., Woelbing F., Brück J., Teske A., Valtcheva N., Fuchs K., Kneilling M., Park J.H., Kim K.H., Kim K.W., Hoffmann P., Krenn C., Hai T., Ghoreschi K., Biedermann T., Röcken M.
  (See online at https://doi.org/10.1038/nm.2557)
• IFN-γ-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients. Molecular Therapy, Vol. 21. 2013, Issue 2, pp. 409-422.
  Riquelme P., Tomiuk S., Kammler A., Florian C., Fändrich F., Schlitt H.J., Geissler E.K., Hutchinson J.A.
  (See online at https://doi.org/10.1038/mt.2012.168)
• TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation. Medical Mycology, Vol. 51. 2013, Issue 8, pp. 818–825.
  Grube M., Loeffler J., Mezger M., Krüger B., Echtenacher B., Hoffmann P., Edinger M., Einsele H., Andreesen R., Holler E.
  (See online at https://doi.org/10.3109/13693786.2013.809630)
• Chondroitin sulfate activates B cells in vitro, expands CD138+ cells in vivo, and interferes with established humoral immune responses. Journal of Leukocyte Biology, Vol. 96, 2014, Issue 1, pp. 65–72.
  Bruhl, H., Cihak, J., Goebel, N., Talke, Y., Renner, K., Hermann, F., Rodriguez-Gomez, M., Reich, B., Plachy, J., Stangassinger, M., Mack, M.
  (See online at https://doi.org/10.1189/jlb.1A0913-502R)
• Killer Artificial Antigen Presenting Cells (KaAPC) for efficient in vitro depletion of human antigen-specific T cells. Journal of Visualized Experiments, Vol. 90. 2014, e51859. (http://www.jove.com/ video/51859)
  Schütz C., Fleck M., Oelke M., Schneck J.P.
  (See online at https://doi.org/10.3791/51859)
• Physiologic TLR9-CpG-DNA interaction is essential for the homeostasis of the intestinal immune system. Inflammatory Bowel Diseases, Vol. 20. 2014, Issue 1, pp. 136–143.
  Hofmann C., Dunger N., Doser K., Lippert E., Siller S., Edinger M., Falk W., Obermeier F.
  (See online at https://doi.org/10.1097/01.MIB.0000436276.19755.c1)
• The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations. Blood, Vol. 123. 2014, Issue 17, pp. e68-e78.
  Schmidl, C., L. Hansmann, T. Lassmann, P.J. Balwierz, H. Kawaji, M. Itoh, J. Kawai, S. Nagao-Sato, H. Suzuki, R. Andreesen, Y. Hayashizaki, A.R. Forrest, P. Carninci, P. Hoffmann, M. Edinger, M. Rehli
  (See online at https://doi.org/10.1182/blood-2013-02-486944)
• Basophils inhibit proliferation of CD4+ T cells in autologous and allogeneic mixed lymphocyte reactions and limit disease activity in a murine model of graft versus host disease. Immunology, Vol. 145. 2015, Issue 2, pp. 202–212.
  Hermann, F., Rodriguez Gomez, M., Doser, K., Edinger, M., Hoffmann, P., Schiechl, G., Brühl, H., Talke,.Y., Göbel, N., Schmidbauer, K., Mack, M.
  (See online at https://doi.org/10.1111/imm.12436)