KFO 146:  Zellvermittelte Suppression von auto- und alloreaktiven Immunreaktionen

• Fachliche Zuordnung: Medizin
• Förderung: Förderung von 2006 bis 2013
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 18407128

• Erstellungsjahr: 2016

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity. Genome Research, Vol. 19. 2009, pp. 1165-1174.
  Schmidl, C., M. Klug, T.J. Boeld, R. Andreesen, P. Hoffmann, M. Edinger, M. Rehli
  (Siehe online unter https://dx.doi.org/10.1101/gr.091470.109)
• Primary human colonic epithelial cells are transiently protected from anoikis by a Src-dependent mechanism. Biochemical and Biophysical Research Communications, Vol. 390. 2009, Issue 3, pp. 908-914.
  Hofmann C, Lippert E, Falk W, Schölmerich J, Rogler G, Obermeier F.
  (Siehe online unter https://doi.org/10.1016/j.bbrc.2009.10.075)
• Basophils support the survival of plasma cells in mice. Journal of Immunology, Vol. 185. 2010, Issue 12, pp. 7180-7185.
  Rodriguez Gomez, M., Talke, Y., Goebel, N., Hermann, F., Reich, B., Mack, M.
  (Siehe online unter https://doi.org/10.4049/jimmunol.1002319)
• Isolation of intact genomic DNA from FOXP3-sorted human regulatory T cells for epigenetic analyses. European Journal of Immunology, Vol. 40. 2010, Issue 5, pp. 1510–1512.
  Hansmann, L., C. Schmidl, T.J. Boeld, R. Andreesen, P. Hoffmann, M. Rehli, M. Edinger.
  (Siehe online unter https://dx.doi.org/10.1002/eji.200940154)
• T-cell dependent protective effects of CpG-ODN in experimental colitis are mediated by CD11c+ dendritic cells. Gut, Vol. 59.2010, Issue 10, pp. 1347-1354.
  Hofmann C., Dunger N., Grunwald N., Hämmerling G.J., Hoffmann P., Schölmerich J., Falk W., Obermeier F.
  (Siehe online unter https://dx.doi.org/10.1136/gut.2009.193177)
• Cutting Edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients. Journal of Immunology, Vol. 187. 2011, Issue 5, pp. 2072-2078.
  Hutchinson J.A., Riquelme P., Sawitzki B., Tomiuk S., Miqueu P., Zuhayra M., Oberg H., Pascher A., Lützen U., Janssen U., Broichhausen C., Renders L., Thaiss F., Scheuermann E., Henze E., Volk H.D., Chatenoud L., Lechler R.I., Wood K.J., Kabelitz D., Schlitt H.J., Geissler E.K., Fändrich F.
  (Siehe online unter https://doi.org/10.4049/jimmunol.1100762)
• Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naive Treg. European Journal of Immunology, Vol. 41. 2011, Issue 5, pp. 1491–1498.
  Schmidl, C., L. Hansmann, R. Andreesen, M. Edinger, P. Hoffmann, M. Rehli
  (Siehe online unter https://dx.doi.org/10.1002/eji.201041067)
• Human regulatory macrophages. In: Suppression and Regulation of Immune Responses - Methods and Protocols, eds.: Maria Cristina Cuturi, Ignacio Anegon. Methods in Molecular Biology(MIMB), Vol. 677. 2011, pp. 181-192.
  Hutchinson JA, Riquelme P, Geissler EK, Fändrich F.
  (Siehe online unter https://doi.org/10.1007/978-1-60761-869-0_13)
• Studies on galactofuranose-containing glycostructures of the pathogenic mold Aspergillus fumigatus. International Journal of Medical Microbiology, Vol. 301. 2011, Issue 6, pp. 523-530.
  Heesemann L., Kotz A., Echtenacher B, Broniszewska M., Routier F., Hoffmann P., Ebel F.
  (Siehe online unter https://doi.org/10.1016/j.ijmm.2011.02.003)
• IL-33 attenuates development and perpetuation of chronic intestinal inflammation. Inflammatory Bowel Diseases, Vol. 18. 2012, Issue 10, pp. 1900–1909.
  Groβ P., Doser K., Falk W., Obermeier F., Hofmann C.
  (Siehe online unter https://doi.org/10.1002/ibd.22900)
• Novel serial positive enrichment technology enables clinical multiparameter cell sorting. PLoS One, Vol. 7. 2012, Issue 4: e35798.
  Stemberger, C., S. Dreher, C. Tschulik, C. Piossek, J. Bet, T.N. Yamamoto, M. Schiemann, M. Neuenhahn, K. Martin, M. Schlapschy, A. Skerra, T. Schmidt, M. Edinger, S.R. Riddell, L. Germeroth, D.H. Busch
  (Siehe online unter https://doi.org/10.1371/journal.pone.0035798)
• Regulatory macrophages as therapeutic targets and therapeutic agents in solid organ transplantation. Current Opinion in Organ Transplantation, Vol. 17. 2012, Issue 4, pp. 332–342.
  Broichhausen C., Riquelme P., Geissler E.K., Hutchinson J.A.
  (Siehe online unter https://doi.org/10.1097/MOT.0b013e328355a979)
• ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression. Nature Medicine, vol. 18. 2012, pp. 128–134.
  Hoetzenecker W., Echtenacher B., Guenova E., Hoetzenecker K., Woelbing F., Brück J., Teske A., Valtcheva N., Fuchs K., Kneilling M., Park J.H., Kim K.H., Kim K.W., Hoffmann P., Krenn C., Hai T., Ghoreschi K., Biedermann T., Röcken M.
  (Siehe online unter https://doi.org/10.1038/nm.2557)
• IFN-γ-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients. Molecular Therapy, Vol. 21. 2013, Issue 2, pp. 409-422.
  Riquelme P., Tomiuk S., Kammler A., Florian C., Fändrich F., Schlitt H.J., Geissler E.K., Hutchinson J.A.
  (Siehe online unter https://doi.org/10.1038/mt.2012.168)
• TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation. Medical Mycology, Vol. 51. 2013, Issue 8, pp. 818–825.
  Grube M., Loeffler J., Mezger M., Krüger B., Echtenacher B., Hoffmann P., Edinger M., Einsele H., Andreesen R., Holler E.
  (Siehe online unter https://doi.org/10.3109/13693786.2013.809630)
• Chondroitin sulfate activates B cells in vitro, expands CD138+ cells in vivo, and interferes with established humoral immune responses. Journal of Leukocyte Biology, Vol. 96, 2014, Issue 1, pp. 65–72.
  Bruhl, H., Cihak, J., Goebel, N., Talke, Y., Renner, K., Hermann, F., Rodriguez-Gomez, M., Reich, B., Plachy, J., Stangassinger, M., Mack, M.
  (Siehe online unter https://doi.org/10.1189/jlb.1A0913-502R)
• Killer Artificial Antigen Presenting Cells (KaAPC) for efficient in vitro depletion of human antigen-specific T cells. Journal of Visualized Experiments, Vol. 90. 2014, e51859. (http://www.jove.com/ video/51859)
  Schütz C., Fleck M., Oelke M., Schneck J.P.
  (Siehe online unter https://doi.org/10.3791/51859)
• Physiologic TLR9-CpG-DNA interaction is essential for the homeostasis of the intestinal immune system. Inflammatory Bowel Diseases, Vol. 20. 2014, Issue 1, pp. 136–143.
  Hofmann C., Dunger N., Doser K., Lippert E., Siller S., Edinger M., Falk W., Obermeier F.
  (Siehe online unter https://doi.org/10.1097/01.MIB.0000436276.19755.c1)
• The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations. Blood, Vol. 123. 2014, Issue 17, pp. e68-e78.
  Schmidl, C., L. Hansmann, T. Lassmann, P.J. Balwierz, H. Kawaji, M. Itoh, J. Kawai, S. Nagao-Sato, H. Suzuki, R. Andreesen, Y. Hayashizaki, A.R. Forrest, P. Carninci, P. Hoffmann, M. Edinger, M. Rehli
  (Siehe online unter https://doi.org/10.1182/blood-2013-02-486944)
• Basophils inhibit proliferation of CD4+ T cells in autologous and allogeneic mixed lymphocyte reactions and limit disease activity in a murine model of graft versus host disease. Immunology, Vol. 145. 2015, Issue 2, pp. 202–212.
  Hermann, F., Rodriguez Gomez, M., Doser, K., Edinger, M., Hoffmann, P., Schiechl, G., Brühl, H., Talke,.Y., Göbel, N., Schmidbauer, K., Mack, M.
  (Siehe online unter https://doi.org/10.1111/imm.12436)