Mathematical modelling and simulation of bone and implant remodelling in the healthy and diseased bone ((07) M08)

• Subject Area: Mathematics ; Orthopaedics, Traumatology, Reconstructive Surgery
• Term: from 2010 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 107540325

The goal of subproject M8 is mathematical modelling, analysis and simulation of the spatiotemporal development of pathologically altered trabecular bone tissue with and without an influence from bone substitute materials, drugs released from implants and malignant plasma cells. In this project, research is focused on the following fields: 1) effects of bone cell population dynamics, mechanical stimuli and drugs on bone remodelling, 2) population dynamics of malignant plasma cells in multiple myeloma with special attention to clonal dynamics and 3) analysis of cell migration, especially during colonization and vascularization of collagen scaffolds and during the immune response in bone healing.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 79: Materials for Tissue Regeneration within Systemically Altered Bone
• Applicant Institution: Justus-Liebig-Universität Gießen
• Project Heads: Dr. Manfred Bobeth, until 6/2014; Professor Dr. Gianaurelio Cuniberti, until 6/2014; Professor Dr. Andreas Deutsch; Professorin Dr. Anna Marciniak-Czochra; Professor Dr. Axel Voigt