Expansion hämatopoetischer Stammzellen durch HOX-Varianten

• Antragsteller: Professor Dr. Michael Heuser
• Fachliche Zuordnung: Hämatologie, Onkologie
• Förderung: Förderung von 2005 bis 2008
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 16933264

• Erstellungsjahr: 2008

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Erythropoietin: Benefits and Concerns. 7th Annual NATA Symposium on Transfusion Medicine and Alternatives, Malaga, Spain, 2006
  Heuser M
  
• Identification of MN1 as a candidate oncogene in hematopoiesis. 35th Annual Scientific meeting of the International Society for Experimental Hematology, Minneapolis, MN, 2006
  Heuser M
  
• MN1 induces leukemia in mice and predicts ATRA resistance and sensitivity in AML patients. 12th Congress of the European Hematology Association Vienna, Austria, 2007
  Heuser M
  
• MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML. Blood. 2007;110:1639-1647
  Heuser M, Argiropoulos B, Kuchenbauer F, et al.
  
• Modulation of the leukemic stem cell activity in MN1-induced leukemias by NUP98HOXD13. 36th Annual Scientific meeting of the International Society for Experimental Hematology, Hamburg, Germany, 2007
  Heuser M
  
• Resistance to retinoic acid in acute myeloid leukemia is mediated by the potent oncogene MN1. 36th Annual Scientific meeting of the International Society for Experimental Hematology, Hamburg, Germany, 2007
  Heuser M
  
• The MN1 oncogene blocks differentiation of multiple hematopoietic lineages. 49th Annual Meeting of the American Society of Hematology Atlanta, GA, 2007
  Heuser M
  
• Use of colony-stimulating factors for chemotherapy-associated neutropenia: review of current guidelines. Semin Hematol. 2007;44:148-156
  Heuser M, Ganser A, Bokemeyer C
  
• Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3. Experimental Hematol. 2008;36:845-859
  Argiropoulos B, Palmqvist L, Yung E, Kuchenbauer F, Heuser M et al.