Activity-dependent developmental plasticity of gaze-stabilizing reflexes (B12)

• Subject Area: Cognitive, Systems and Behavioural Neurobiology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 118803580

Gaze-stabilization during self-motion requires spatio-temporally adequate sensory-motor transformations and integration with locomotor efference copies. The neuronal circuitries for these computations are formed during embryogenesis but are functionally tuned only post-embryonically. This proposal aims at deciphering mechanistic principles such as the role of intrinsic reference frames and activity-dependent plasticity for brainstem and cerebellar circuit formation and spatio-temporal maturation of vestibular reflexes. The outcome of this proposal will reveal important general rules and requirements for the ontogenetic tuning of sensory-motor integrations necessary for gaze-stabilization.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 870: Assembly and Function of Neuronal Circuits in Sensory Processing
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Hans Straka (†)