Regulation of vascular repair and remodelling by non-coding RNAs (B01)

• Subject Area: Cardiology, Angiology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 75732319

Non-coding RNAs comprise <200 nucleotide small non-coding RNAs, such as microRNAs, as well as long non-coding RNAs. Whereas microRNAs are well established as regulators of mRNA stability and translation, lncRNAs have multiple functions and their role in the cardiovascular system is mainly unclear. We determined the regulation and function of microRNAs and lncRNAs with respect to atherosclerotic disease in mouse models and humans. In the next funding period, we will determine the role and mechanism of action of the lnRNAs MALAT1 and NEAT1 in vascular remodelling. Moreover, we will use single cell sequencing to decipher the regulation of microRNAs and lncRNAs in circulating endothelial cells in humans by coronary artery disease.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 834: Endothelial Signalling and Vascular Repair
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professorin Dr. Stefanie Dimmeler; Privatdozent Dr. Stephan Fichtlscherer, until 12/2017; Privatdozentin Dr. Mariuca Vasa-Nicotera