Metabolic programming of endothelial cells by vascular NADPH oxidases (A02)

• Subject Area: Anatomy and Physiology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 75732319

NADPH oxidases of the Nox family are important sources of reactive oxygen species (ROS), which influence physiological cell function and cardiovascular disease development. In the current funding period, we will identify the vascular function of the subunit NoxO1, which controls Nox activity. We will identify its contribution to inflammatory signalling and its role in atherosclerosis development. We will also determine the impact of Nox-derived ROS on cellular metabolism and its subsequent consequences for cell and organ function. A specific focus will be the function of Nox enzymes in the glycolytic switch as well as in the hexosamine pathway.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 834: Endothelial Signalling and Vascular Repair
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professor Dr. Ralf P. Brandes; Professorin Katrin Schröder, Ph.D.