Neue Strategien zur Verbesserung der Pharmakokinetik und Aktivität rekombinanter, bispezifischer Antikörpermoleküle

• Applicant: Professor Dr. Roland Kontermann
• Subject Area: Immunology
• Term: from 2005 to 2009
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 14761343

• Final Report Year: 2009

Final Report Abstract

No abstract available

Publications

• (2007) A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispecific single-chain diabody with an albumin-binding domain from streptococcal protein G. Protein Eng. Design Sel. 20, 569-576
  Stork, R., Müller, D. & Kontermann, R.E.
  
• (2007) Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin. J. Biol. Chem. 282, 12650-12660
  Müller, D., Karle, A., Meißburger, B., Höfig, I., Stork, R. & Kontermann, R.E.
  
• (2008) N-glycosylation as novel strategy to improve pharmacokinetic properties of bispecific single-chain diabodies. J. Biol. Chem. 283,7804-7812
  Stork, R., Müller, D. & Kontermann, R.E.