Verbesserung der HIV Env Antikörperantwort durch intrastrukturelle Hilfe von heterologen T-Helfer-Zellen (C02)

• Subject Area: Virology
• Term: from 2009 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 47100475

Gag-specific T-helper cells increase the Env antibody response in mice after booster immunizations with virus-like particles (VLPs) containing Gag and Env by the intrastructural help mechanism. The aim of the current project is to exploit this intrastructural help to modulate the antibody response to HIV Env by heterologous T helper cells. Mice will be immunized against heterologous antigens prior to booster immunizations with VLPs containing the heterologous antigens inside. By using different modes of priming against the heterologous antigens, we aim to modulate the humoral immune response to the HIV Env with a particular focus on inducing mucosal immune responses.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 60: Mutual Interaction of Viruses with Cells of the Immune System: From Fundamental Research to Immunotherapy and Vaccination
• Applicant Institution: Universität Duisburg-Essen
• Co-Applicant Institution: Ruhr-Universität Bochum
• Project Head: Professor Dr. Klaus Überla, until 1/2015