Project Details

Professor Dr. Rolf Backofen

Address Albert-Ludwigs-Universität Freiburg
Institut für Informatik
Lehrstuhl für Bioinformatik
Georges-Köhler-Allee 106
79110 Freiburg

Projects

As Applicant
- Current projects
  - Impact of RNA-binding proteins and mRNA structures on alternative mechanisms of translational regulation in inflammation-associated tumorigenesis (Research Grants)
  - Ribosome Profiling and Bioinformatics (Priority Programmes)
  - Early Determinants of Heterocyst Differentiation in Multicellular Cyanobacteria (Priority Programmes)
- Completed projects
  - Algorithmic determination of whether a protein`s cysteine residue can be replaced by selenocysteine by silent/similiar pointwise mutagenesis in DNA/RNA. Intended application to phase determination in X-ray crystallography and NMR spectroscopy. (Priority Programmes)
  - Computational Detection of Bacterial ncRNAs and their Targets (Priority Programmes)
  - Extending the theory of Algebraic Dynamic Programming for applications in bioinformatics (Research Grants)
  - A Flexible and Efficient System for the Detection of RNA Sequence/Structure Motifs (Research Grants)
  - MiRNA and RNA-binding proteins as integral part of cell communication:context-based target prediction and validation (Priority Programmes)
  - Bioinformatic analyses of CRISPR elements (Research Units)
  - ATP - Automated Intra-Annual Tree-Ring Profiling for Dendroecological Research (Research Grants)
  - The population genetics of the CRISPR-Cas system in bacteria (Priority Programmes)
  - eCLASH Towards defining the small RNA interactome (Research Grants)
  - Prediction of RNA-RNA Interactions by Kinetic Modelling (Research Grants)
  - Functional characterisation of the non-coding RNA Pantr1 in FOXG1-dependent forebrain development and Rett-syndrome (Priority Programmes)
  - Service Project: "CRISPR Bioinformatics" (Priority Programmes)
As Leader
- Completed projects
  - High-Performance Computing (HPC) Cluster (Major Research Instrumentation)
As Participating Researcher
- Current projects
  - GRK 2344: MeInBio - BioInMe: Exploration of spatio-temporal dynamics of gene regulation using high-throughput and high-resolution methods (Research Training Groups)
As Project Head
- Current projects
  - Bioinformatics core (CRC/Transregios)
  - An effective similarity integration multi-modal graph neural network method to facilitate disease gene prioritization (Collaborative Research Centres)
  - Enabling efficient and safe application of CRISPR-Cas in primary human cells by deep learning-based information transfer from well-investigated cell types (Collaborative Research Centres)
  - Integrated research training group (Collaborative Research Centres)
  - Sequencing and Bioinformatics (Collaborative Research Centres)
- Completed projects
  - Alternative Splicing as a Modulator of Signal Transduction (Collaborative Research Centres)
  - Deep-Sequencing / Bioinformatics (Collaborative Research Centres)
As Participating Person
- Current projects
  - DataPLANT – Data in PLANT research (NFDI technical and methodological consortia)
As Cooperation Partner
- Completed projects
  - The CRISPR/Cas system in Neisseria meningitidis and its potential role in host cell adhesion (Priority Programmes)

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Professor Dr. Rolf Backofen

Additional Information

Servicenavigation

Hauptnavigation

Professor Dr. Rolf Backofen

Additional Information

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