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Professor Dr. Thomas Pap

Address Universitätsklinikum Münster
Institut für Muskuloskelettale Medizin
Albert-Schweitzer-Campus 1
48149 Münster

Projects

As Applicant
- Current projects
  - Matrix mediated fibroblast activation in rheumatoid arthritis (Research Units)
- Completed projects
  - Modulation der Aggressivität synovialer Fibroblasten bei Rheumatoid Arthritis durch retroviralen Gentransfer von Antisensekonstrukten gegen Apoptoseinhibitoren (Independent Junior Research Groups)
  - Untersuchung zur Entstehung und Beeinflussung von Frühstadien der Membranentstehung bei aseptischer Endoprothesenlockerung in einem Wistarratten-Modell (Independent Junior Research Groups)
  - Expression von IL-16 in synovialen Fibroblasten (Research Grants)
  - Mechanismen der Apoptoseregulation durch SUMO-spezifische Proteasen in synovialen Fibroblasten von Patienten mit rheumatoider Arthritis (Research Grants)
  - Das LIM-Domänen Protein FHL2 als neuer Regulator des aggressiv-invasiven Verhaltens synovialer Fibroblasten bei rheumatoider Arthritis. (Research Grants)
  - Die Rolle der SUMO-Protease SENP7 bei der stabilen Aktivierung synovialer Fibroblasten bei rheumatoider Arthritis. (Research Grants)
  - Regulation of cytokine-dependent calcification of cartilage tissue by NPP1 and syndecan-4 (Research Grants)
  - Das autonom zellgängige bakterielle Effektorprotein YopM als neues biologisches Therapeutikum der rheumatoiden Arthritis (Research Grants)
  - Regulation of inflammatory bone destruction in rheumatoid arthritis by the small ubiquitin-like modifyer SUMO-1 (Research Grants)
  - Regulation of fibroblast response to IL-1 in rheumatoid arthritis by the transmembrane heparane sulfate proteoglycan syndecan-4 (Research Grants)
As Leader
- Completed projects
  - Micro-CT (Major Research Instrumentation)
As Project Head
- Completed projects
  - Regulation of Fibroblast Attachment and Invasiveness by PI3KGamma-Mediated Signalling Pathways in Rheumatoid Arthritis (Collaborative Research Centres)
  - Mechanisms of transendothelial fibroblast migration in rheumatoid arthritis (Collaborative Research Centres)
  - Myostatin-induced mechanisms of inflammatory bone and cartilage destruction by invasive fibroblast-like synoviocytes (Collaborative Research Centres)
As Participating Person
- Completed projects
  - Maligne Knochentumore: Modulation von Apoptose und Invasion durch den Gewebeinhibitor von Metalloproteinasen-3 (TIMP-3) (Research Grants)
  - Krankheitsspezifische Induktion der Serinprotease FAP in der rheumatoiden Arthritis: Funktion und Regulation bei der osteoklastären Knochendestruktion. (Research Grants)
  - Untersuchung der rheumatischen Knorpelzerstörung mit Hilfe eines neu etablierten in vitro Modells (MATRIN-Assay) unter Verwendung von authentischen Kollagenmatrizes (Research Grants)
  - Syndecan-4 as a regulator of chondroblast development during fracture healing (Research Grants)
  - Crosstalk between inflammation, bone destruction and new bone formation in patients with ankylosing spondylitis (Priority Programmes)
  - The role of myostatin in joint destruction in rheumatoid arthritis (Priority Programmes)
  - Heparan sulfate in Degenerating Joint Diseases (Priority Programmes)
  - The role of the heparansulfate proteoglycan syndecan-1 in bone metabolism (Research Grants)
As Co-Investigator
- Completed projects
  - The protective function of the Wnt inhibitor sclerostin in inflammatory bone destruction. (Research Grants)
  - The impact of myostatin on breast cancer and multiple myeloma bone metastases (Priority Programmes)

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