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Professor Dr. Michael Hallek

Address Uniklinik Köln
Klinik für Innere Medizin I
Kerpener Straße 62
50937 Köln

Projects

As Applicant
- Completed projects
  - Charakterisierung von Src-Kinasen als molekulare Zielstruktur für die Therapie Philadelphia-positiver Leukämien. (Research Grants)
  - Recombinant adeno-associated virus-mediated transgene delivery into porcine organs to allow immunological modifications of xenografts (Research Units)
  - In vitro und in vivo Targeting von Melanomzellen mit Hilfe kapsidmodifizierter AAV2-Vektoren (Research Grants)
  - Combinatorial selection of efficient and cell-type specific adeno-associated virus vectors (AAV) for human gene therapy (Research Grants)
  - Function of tyrosine kinases Lyn and Btk in high-risk CLL (Clinical Research Units)
  - Lyn kinase as a key regulator in the microenvironmental niche of B lymphoid tumors (Research Grants)
As Spokesperson
- Current projects
  - SFB 1530: Elucidation and targeting of pathogenic mechanisms in B cell malignancies (Collaborative Research Centres)
- Completed projects
  - SFB 832: Molecular Basis and Modulation of Cellular Interactions in the Tumour Microenvironment (Collaborative Research Centres)
  - KFO 286: Exploiting Defects in the DNA Damage Response for the Treatment of Chronic Lymphocytic Leukemia (Clinical Research Units)
As Participating Researcher
- Completed projects
  - EXC 229: Cellular Stress Responses in Aging-Associated Diseases (Clusters of Excellence)
As Project Head
- Current projects
  - LYN kinase as a key regulator in the microenvironmental niche of B cell lymphoid tumors (Collaborative Research Centres)
  - Central administration project (Collaborative Research Centres)
- Completed projects
  - Targeting von rekombinanten Adeno-assoziierten Virus-Vektoren (Collaborative Research Centres)
  - Bestimmung der antigen-Spezifität der T-Zellantwort gegen eine genmodifizierte, polyvalente Vakzine bei der chronischen lymphatischen Leukämie (CLL) (Collaborative Research Centres)
  - Molecular modulation of leukemia-associated macrophages in the microenvironment of chronic lymphocytic leukemia (CLL) (Collaborative Research Centres)
  - Central administration (Collaborative Research Centres)
  - Cell autonomous immune responses towards Adeno-associated virus (AAV) infection in the liver (Collaborative Research Centres)
As Participating Person
- Completed projects
  - Adenoassoziiertes Virus (AAV)-vermittelter Gentransfer zur Vermeidung von Venenbypass-Restenosen (Research Grants)
  - Pathogenese der HIV-induzierten Blut-Hirn-Schrankenstörung und neuronalen Schädigung: Bedeutung des HIV-1-Regulatorproteins Nef (Research Grants)
  - Zelleintritt und intrazelluläre Prozessierung von rAAV targeting Vektoren und ihrer Genome im lympho-hämatopoetischen System (Priority Programmes)
As Co-Investigator
- Completed projects
  - Long-read sequencing of SF3B1 mutated and wildtype chronic lymphocytic leukemia and myelodysplastic syndrome to identify mechanisms of genomic instability and therapy resistance and their impact on prognosis. (Research Grants)

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