Project Details

Professorin Dr. Annette G. Beck-Sickinger

Address Universität Leipzig
Institut für Biochemie
Arbeitsgruppe Biochemie und Bioorganische Chemie
Brüderstraße 34
04103 Leipzig

Projects

As Applicant
- Current projects
  - Structure Elucidation of the Neuropeptide Y5 Receptor- Relevant in Food intake and Cancer (Research Grants)
- Completed projects
  - Constrained analogues of neuropeptides to identify the bioactive conformation at different receptors and develop subtype selective ligands (Research Grants)
  - Dynamics of the molecular recognition of G-protein-coupled-receptor/ligand interaction: neuropeptide Y and interleukin 8 (Research Grants)
  - Identifizierung der Rezeptorinteraktion von RF-amid-Peptiden auf molekularer Ebene (Research Grants)
  - Markierung von Peptidhormonen mit Metallkomplexen für Tumordiagnostik und -therapie (Research Units)
  - Atherobesity: Molekulare Mechanismen (Clinical Research Units)
  - Ensemble Docking Interrogates Structural Determinants of Ligand-Protein Interactions (Research Grants)
  - Peptide-templated bioconjugation of proteins on and in live cells for studies of GPCR trafficking and crosstalk (Priority Programmes)
As Leader
- Completed projects
  - Konfokales High-Content Imaging System (Major Research Instrumentation)
  - MALDI-ToF mass spectrometer (Major Research Instrumentation)
As Spokesperson
- Current projects
  - SFB 1423: Structural Dynamics of GPCR Activation and Signaling (Collaborative Research Centres)
- Completed projects
  - SFB 610: Variation in Protein Conformation: Cellbiological and Pathological Relevance (Collaborative Research Centres)
As Participating Researcher
- Completed projects
  - GRK 378: Mechanisms and Applications of Non-Conventional Oxidation Reactions (Research Training Groups)
  - GSC 185: Leipzig School of Natural Sciences - Building with Molecules and Nano-objects (BuildMoNa) (Graduate Schools)
As Project Head
- Current projects
  - Targeting of central peptide receptors via nasal ligand application to modulate food intake (Collaborative Research Centres)
  - Targeted delivery of drugs into adipocytes by peptide-mediated shuttling in a new obesity mouse model (Collaborative Research Centres)
  - Development of modulators at the chemokine-like receptor to elucidate its role in obesity (Collaborative Research Centres)
  - Characterizing the molecular interactions between Y receptors and arrestin (Collaborative Research Centres)
  - Molecular mechanisms of allosteric modulators at Y-receptors (Collaborative Research Centres)
  - Central Administration (Collaborative Research Centres)
  - Peptide synthesis and membrane protein (GPCR) expression (Collaborative Research Centres)
- Completed projects
  - On the role of protein loops in the biosynthesis and in the ligand-receptor interaction of the neuropeptide Y system (Collaborative Research Centres)
  - Zentrale Aufgaben des Sonderforschungsbereichs (Collaborative Research Centres)
  - Chemical modification of proteins for the characterization of matrix-protein interactions (CRC/Transregios)
  - Integrated Research Training Group "Matrix Engineering" (CRC/Transregios)
  - Molecular Mechanisms of Action of Adipokines (Collaborative Research Centres)
As Participating Person
- Completed projects
  - Directed evolution of bacterial polysialyltransferases for structural studies and their application for enzymatic polysialylation of therapeutic proteins (Research Fellowships)

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Hauptnavigation

Professorin Dr. Annette G. Beck-Sickinger

Additional Information

Servicenavigation

Hauptnavigation

Professorin Dr. Annette G. Beck-Sickinger

Additional Information

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