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Molecular pathways controlling cell type specification in the cerebral cortex

Subject Area Developmental Neurobiology
Term from 2008 to 2014
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 93329385
 
Final Report Year 2015

Final Report Abstract

Our main discoveries from 2008: 1. We discovered a mechanism that controls cell fate switch of neocortical progenitors based on “feedback” (more details below). 2. We discovered the mechanism that controls axonal guidance of neocortical axons downstream of Satb2 transcription factor. 3. We discovered the role of NeuroD transcription factors in the necortical cell fate and connectivity. 4. We discovered the role of NOMA-GAP in the neocortical dentritogenesis. 5. We discovered the role of neurotrophin-TrkC signaling in the cell fate specification in the developing neocortex.

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