Project Details
Projekt
Modulation of ß-catenin-independent Wnt-signaling by secreted frizzled related proteins (sFRPs)
Applicant
Dr. Lilian Tamara Kaufmann, since 12/2014
Subject Area
Developmental Biology
Term
from 2009 to 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 58160712
The Wnt signaling cascade consists of different branches which are either dependent or independent of β-catenin. Wnt signaling regulates various processes during embryonic development and is implicated in human diseases such as various forms of cancer, deafness and spina bifida. In this project we plan to investigate the role of a novel splicing variant of Frizzled receptor 4 and the secreted Frizzled related proteins (sFRPs) in modulating Wnt signaling. As an experimental model we will use Xenopus laevis embryos which offer excellent assay systems for the analysis of both, β-catenin-dependent and independent Wnt signaling.
DFG Programme
Research Units
Ehemaliger Antragsteller
Professor Dr. Herbert Steinbeisser, until 12/2014 (†)
