GRK 1167:  Cell-cell Communication in Neural and Immune Systems: Topological Organisation of Signal Transduction

• Subject Area: Neurosciences ; Medicine
• Term: from 2005 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 812229

• Final Report Year: 2015

Final Report Abstract

Die Kommunikation zwischen Zellen ist eine essentielle biologische Funktion in vielzelligen Organismen. Während der Evolution haben sich prinzipielle Mechanismen der Zell-Zell-Kommunikation entwickelt, die dann eine Organ-, Gewebe- oder zelltypspezifische Anpassung erfahren haben. Ziel des Graduiertenkollegs war es, molekulare Mechanismen der zellulären Kommunikation und Signaltransduktion in Immun- und Nervensystem vergleichend zu untersuchen und Kollegiaten durch fachübergreifende Ausbildung zur Spitzenforschung auf diesem Gebiet zu qualifizieren. Das Kolleg stützte sich dabei auf das Potenzial der vor Ort etablierten international sichtbaren Forschungsschwerpunkte Immunologie/Molekulare Medizin der Entzündung und Neurowissenschaften. Es umfasste Hochschullehrer aus den Fakultäten für Medizin und für Naturwissenschaften der Otto-von-Guericke-Universität sowie des Leibniz-Instituts für Neurobiologie. Die interdisziplinäre Forschung zur molekularen Interaktion von Zellen des Immun- und des Nervensystems wurde dadurch am Wissenschaftsstandort Magdeburg gestärkt. Die Grundlagenforschung des Kollegs wurde darüber hinaus durch Projekte mit medizinisch-klinisch relevantem Hintergrund ergänzt, die die molekularen Mechanismen pathophysiologisch aberranter Zell-Zell-Kommunikation und Signaltransduktion erforschten. Das Studienprogramm, das die Forschungsarbeiten in den Projekten begleitete und vernetzte, verfolgte das Ziel einer umfassenden Befähigung zu selbstständiger wissenschaftlicher Arbeit auf dem Gebiet molekularer und zellulärer Fragestellungen in den Neurowissenschaften und der Immunologie. Die Verwandtschaft der in den Projekten benötigten Methoden und Technologien stellte ein zusätzliches synergistisches Element in Ausbildung und Forschung dar. Schlüsseltechnologien wie Massenspektrometrie, Bildgebende Verfahren und Bioinformatik wurden für alle Projekte gleichermaßen vorgehalten. Das Kolleg diente insgesamt als Kristallisationspunkt und Integrationselement für die Kooperation der beteiligten Forschungsschwerpunkte und unterstützte die internationale Spitzenforschung auf den Arbeitsgebieten vor Ort.

Publications

• 2006. The ADAP/SKAP55 signaling module regulates T-cell receptormediated integrin activation through plasma membrane targeting of Rap1. Mol Cell Biol. 26: 7130-7144
  Kliche S, D Breitling, M Togni, R Pusch, K Heuer, X Wang, C Freund, A Kasirer-Friede, G Menasche, GA Koretzky, B Schraven
  
• 2007. A reduced number of cortical neurons show increased caldendrin protein levels in chronic schizophrenia. Schizophr Res. 184: 246-256
  Bernstein HG, J Sahin, KH Smalla, ED Gundelfinger, B Bogerts, MR Kreutz
  
• 2007. Immune control by endocannabinoids - new mechanisms of neuroprotection? J Neuroimmunol. 184: 127-135
  Ullrich O, K Merker, J Timm, S Tauber
  
• 2007. Specific expression of low-voltage-activated calcium channel isoforms and splice variants in thalamic local circuit interneurons. Mol Cell Neurosci. 36: 132-145
  Broicher T, T Kanyshkova, P Landgraf, V Rankovic, P Meuth, SG Meuth, HC Pape, T Budde
  
• 2008. A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia. Mol Psychiatry 13: 878-896
  Smalla KH, M Mikhaylova, J Sahin, HG Bernstein, B Bogerts, A Schmitt, R van der Schors, AB Smit, KW Li, ED Gundelfinger, MR Kreutz
  
• 2008. CNS immune surveillance and neuroinflammation: endocannabinoids keep control. Curr Pharm Des. 14: 2266-2278
  Wolf SA, S Tauber, O Ullrich
  
• 2008. Dissecting the molecular mechanisms in craniofrontonasal syndrome: differential mRNA expression of mutant EFNB1 and the cellular mosaic. Eur J Hum Genet. 16: 184-191
  Wieland I, R Makarov, W Reardon, S Tinschert, A Goldenberg, P Thierry, P Wieacker
  
• 2008. Dynamics of proximal signaling events after TCR/CD8-mediated induction of proliferation or apoptosis in mature CD8+ T-cells. J Immunol. 180: 6703-6712
  Wang X, L Simeoni, JA Lindquist, J Saez-Rodriguez, ED Gilles, S Kliche, B Schraven
  
• 2008. LS104, a non-ATP-competitive small-molecule inhibitor of LAK2, is potently inducing apoptosis in JAK2V617F-positive cells. Mol Cancer Ther. 7: 1176-1184
  Lipka DB, LS Hofmann, F Heidel, B Markova, MC Blum , F Breitenbücher, S Kasper, T Kindler, RL Levine, C Huber, T Fischer
  
• 2008. NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2. J Invest Dermatol. 128: 1134-1147
  Diessenbacher P, M Hupe, MR Sprick, A Kerstan, P Geserick, TL Haas, T Wachter, M Neumann, H Walczak, J Silke, M Leverkus
  
• 2008. Protein kinase C-θ critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis. J Immunol. 180: 5601-5612
  Sakowicz-Burkiewicz M, G Nishanth, U Helmuth, K Drögemüller, DH Busch, O Utermöhlen, M Naumann, M Deckert, D Schlüter
  
• 2008. Regulation of T cell homeostasis by the transmembrane adaptor protein SIT. J Immunol. 180: 1634-1642
  Posevitz V, B Arndt, T Krieger, N Warnecke, B Schraven, L Simeoni
  
• 2008. Suppression of cFLIP is sufficient to sensitize human melanoma cells to TRAIL- and CD95L-mediated apoptosis. Oncogene 27: 3211-3220
  Geserick P, C Drewniok, M Hupe, TL Haas, P Diessenbacher, MR Sprick, MP Schön, F Henkler, H Gollnick, H Walczak, M Leverkus
  
• 2009. Adpribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2. Cell Signal. 12: 1784-1793
  Rankovic M, L Jacob, V Rankovic, LO Brandenburg, H Schröder, V Höllt, T Koch
  
• 2009. Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitiazion of the mu-opinoid receptor. Neuropharmacology 56: 768-778
  Schröder H, DF Wu, A Seifert, M Rankovic, S Schulz, V Höllt, T Koch
  
• 2009. alphaA-crystallin and alphaB-crystallin, newly identified interaction proteins of protease-activated receptor-2 (PAR-2), rescue astrocytes from C2-ceramideand staurosporine-induced cell death. J Neurochem. 110: 1433-1444
  Li R, T Rohatgi, T Hanck, G Reiser
  
• 2009. Altered Postsynaptic-Density-Levels of Caldendrin in the Para-Chloroamphetamine-Induced Serotonin Syndrome but not in the Rat Ketamine Model of Psychosis. Neurochem Res. 34: 1405-1409
  Smalla KH, J Sahin, J Putzke, W Tischmeyer, ED Gundelfinger, MR Kreutz
  
• 2009. Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. J Cell Biol. 187: 1037-1054
  Geserick P, M Hupe, M Moulin, WW Wong, M Feoktistova, B Kellert, H Gollnick, J Silke, M Leverkus
  
• 2009. Dendritic mRNA targeting of Jacob and N-methyl-d-aspartateinduced nuclear translocation after calpain-mediated proteolysis. J Biol Chem. 284: 25431-25440
  Kindler S, DC Dieterich, J Schütt, J Sahin, A Karpova, M Mikhaylova, C Schob, ED Gundelfinger, H- J Kreienkamp, MR Kreutz
  
• 2009. Dynamics of proximal signaling events after TCR/CD8+-mediated induction of proliferation or apoptosis in mature CD8 T cells
  Wang, X
  
• 2009. Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon. J Cell Biol. 185: 341-355
  Fejtova A, D Davydova, F Bischof, V Lazarevic, WD Altrock, S Romorini, C Schöne, W Zuschratter, MR Kreutz, CC Garner, NE Ziv, ED Gundelfinger
  
• 2009. Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection. Exp Cell Res. 315: 3500-3508
  Schirrmeister W, T Gnad, T Wex, S Higashiyama, C Wolke, M Naumann, U Lendeckel
  
• 2009. Modulation of Ca2+-dependent inactivation of Ca2+-channels by intracellular signaling
  Rankovic, V
  
• 2009. Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out-signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion and migration of T-cells. J Immunol. 183: 5756-5767
  Horn J, X Wang, P Reichardt, TE Stradal, N Warnecke, L Simeoni, M Gunzer, D Yablonski, B Schraven, S Kliche
  
• 2009. µ-Opioid receptor-stimulated synthesis of reactive oxygen species (ROS) is mediated via phospholipase D2. J Neurochem. 110: 1288-1296
  Koch T, A Seifert, DF Wu, M Rankovic, J Kraus, C Börner, LO Brandenburger, H Schröder, V Höllt
  
• 2010. Cell Commun Signal. 8: 12
  Wolf SA, A Bick-Sander, K Fabel, P Leal-Galicia, S Tauber, G Ramirez-Rodriguez, A Müller, A Melnik, TP Waltinger, O Ullrich
  
• 2010. Disruption of fear memory consolidation and reconsolidation by actin filament arrest in the basolateral amygdala. Neurobiol Learn Mem. 94: 117-126
  Rehberg K, JR Bergado-Acosta, JC Koch, O Stork
  
• 2010. Expression and functional analysis of EFNB1 mutations in craniofrontonasal syndrome
  Makarov, R
  
• 2010. Helicobacter pylori-induced activation of β-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled. Mol Cancer 9: 31
  Gnad T, M Feoktistova , M Leverkus, U Lendeckel, M Naumann
  
• 2010. Intracellular Ca2+ release-dependent inactivation of Ca2+ currents in thalamocortical relay neurons. Eur J Neurosci. 31: 439-449
  Rankovic V, P Ehling, P Coulon, P Landgraf, MR Kreutz, T Munsch, T Budde
  
• 2010. Mechanisms of assembly and activity-dependent remodeling of the presynaptic cytomatrix at the active zone
  Lazarevic, V
  
• 2010. Modulation des kanonischen Wnt/β−Catenin-Signalweges in der Helicobacter pylori- Infektion
  Gnad, T
  
• 2010. Modulation of µ-opioid receptor signal transduction and endocytosis by ADP- ribosylation factor proteins
  Rankovic, M
  
• 2010. Molecular determinants for the subcellular distribution of the synapto-nuclear protein messenger Jacob
  Sahin, J
  
• 2010. Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelialcells. Cell Signal. 22: 395-403
  Rieke C, T Kähne, K Schweitzer, B Schraven, M Engelke, J Wienands, M Naumann
  
• 2010. Protease-activated receptor 2 and α-crystallins: Interactions and functional implications
  Li, R
  
• 2010. Protective Toxoplasma gondii-specific T-Cell Responses Require T-Cell-Specific Expression of Protein Kinase C-Theta. Infect Immun. 78: 3454-3464
  Nishanth G, M Sakowicz-Burkiewicz, U Händel, S Kliche, X Wang, M Naumann, M Deckert, D Schlüter
  
• 2010. Regulation und Funktion der Adapterproteine NTAL und LIME in Helicobacter pyloriinfizierten Epithelzellen
  Rieke, C
  
• 2010. RIP-in CD95-induced cell death: The control of alternative death receptors pathways by cIAPs. Cell Cycle. 9: 2689-2691
  Geserick P, M Hupe, M Moulin, M Leverkus
  
• 2010. Role of phospholipase D2/phosphatidic acid signal transduction in micro- and delta-opioid receptor endocytosis. Mol Pharmacol. 78: 105-113
  Yang L, A Seifert, D Wu, X Wang, V Rankovic, H Schröder, LO Brandenburg, V Höllt, T Koch
  
• 2010. Roles of Bassoon in assembling the presynaptic active zone for neurotransmitter release
  Davydova, D
  
• 2010. The contact allergen nickel sensitizes primary human endothelial cells and keratinocytes to TRAIL- mediated apoptosis. J Cell Mol Med. 14: 1760-1776
  Schmidt M, M Hupe, N Endres, B Raghavan, S Kavuri, P Geserick, M Goebeler, M Leverkus
  
• 2010. The impact of CFNS-causing EFNB1 mutations on ephrin-B1 function. BMC Med Genet. 11:98
  Makarov R, B Steiner, Z Gucev, V Tasic, P Wieacker, I Wieland
  
• 2011. Apoptotic and non-apoptotic death receptor signaling pathways and their regulation by cFLIP, cIAPs and RIP1 in the skin
  Hupe, M
  
• 2011. Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex. J Biol Chem. 286: 16631-16646
  Kavuri SM, P Geserick, D Berg, DP Dimitrova, M Feoktistova, D Siegmund, H Gollnick, M Neumann, H Wajant, M Leverkus
  
• 2011. cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms. Mol Cell. 43: 449-463
  Feoktistova M, P Geserick, B Kellert, DP Dimitrova, C Langlais, M Hupe, K Cain, M Macfarlane, G Häcker, M Leverkus
  
• 2011. Die funktionelle Bedeutung der Serin/Threonin-Kinase Ndr2 in Integrin- Signalwegen für die Differenzierung neuronaler Zellen
  Rehberg, K
  
• 2011. Extensive Remodeling of the Presynaptic Cytomatrix upon Homeostatic Adaptation to Network Activity Silencing. J Neurosci. 31: 10189-10200
  Lazarevic V, C Schöne, M Heine, ED Gundelfinger, A Fejtova
  
• 2011. Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation. J Immunol. 186: 6521-6531
  Haroon F, K Drögemüller, U Händel, A Brunn, D Reinhold, G Nishanth, W Mueller, C Trautwein, M Ernst, M Deckert, D Schlüter
  
• 2011. Helicobacter pylori-induced tyrosine phosphorylation of IKKβ contributes to NF-κB activation. Biol Chem. 392: 387-393
  Rieke C, A Papendieck, O Sokolova, M Naumann
  
• 2011. Modulation of calcium-dependent inactivation of L-type Ca channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One. 6: e27474
  Rankovic V, P Landgraf, T Kanyshkova, P Ehling, SG Meuth, MR Kreutz, T Budde, T Munsch
  
• 2011. Oxidoreductase activity of multifunctional monoclonal antibody B13DE1. J Mol Recognit. 24:930-934
  Messerschmidt K, J Degen, B Micheel.
  
• 2011. Phosphorylation of Ser45 and Ser59 of αB-crystallin and p38/extracellular regulated kinase activity determine αB-crystallin-mediated protection of rat brain astrocytes from C2- ceramide- and staurosporine-induced cell death. J Neurochem. 118: 354-364
  Li R, G Reiser
  
• 2011. Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca2+ sensor calneurons requires the TRC40/Asna1 protein chaperone. J Biol Chem. 286: 36762-36776
  Hradsky J, v Raghuram, PP Reddy, G Navarro, M Hupe, V Casado, PJ McCormick, Y Sharma, MR Kreutz, M Mikhaylova
  
• 2011. Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo. Plos One. 6:e17314
  Hasenberg M, A Köhler, S Bonifatius, K Borucki, M Riek-Burchardt, J Achilles, L Männ, K Baumgart, B Schraven, M Gunzer
  
• 2011. The cannabinoid receptors agonist WIN55212-2 inhibits macrophageal differentiation and alters expression and phosphorylation of cell cycle control proteins. Cell Commun Signal. 9: 33
  Paulsen K, S Tauber, J Timm, N Goelz, C Dumrese, A Stolzing, R Hass, O Ullrich
  
• 2011. The role of RIP-1 and CIAPs in apoptotic and non-apoptotic signaling via TLR3 and death receptors
  Feoktistova, M
  
• 2011. The SLP-76 Src homology 2 domain is required for T cell development and activation. J Immunol. 187: 4459-4466
  Burns JC, E Corbo, J Degen, M Gohil, C Anterasian, B Schraven, GA Koretzky, S Kliche, MS Jordan
  
• 2011. The transmembrane adaptor protein SIT inhibits TCR-mediated signaling. PLoS One. 6: e23761
  Arndt B, T Krieger, T Kalinski, A Thielitz, D Reinhold, A Roessner, B Schraven, L Simeoni
  
• 2012. 3,4-Diarylmaleimides-a novel class of kinase inhibitorseffectively induce apoptosis in FLT3-ITD-dependent cells. Ann Hematol. 91: 331-344
  Heidel FH, Mack TS, Razumovskaya E, Blum MC, Lipka DB, Ballaschk A, Kramb JP, Plutizki S, Rönnstrand L, Dannhardt G, Fischer T
  (See online at https://doi.org/10.1007/s00277-011-1311-3)
• 2012. CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55-modules. Blood. 119: 777-785
  Kliche S, T Worbs, X Wang, J Degen, I Patzak, B Meineke, M Togni, M Moser, A Reinhold, F Kiefer, C Freund, R Förster, B Schraven
  (See online at https://doi.org/10.1182/blood-2011-06-362269)
• 2012. Differential spatial expression and subcellular localization of CtBP family members in rodent brain. PLoS One. 6: e39710
  Hübler D, M Rankovic, K Richter, V Lazarevic, WD Altrock, KD Fischer, ED Gundelfinger, A Fejtova
  (See online at https://doi.org/10.1371/journal.pone.0039710)
• 2012. Emerging roles of ADAP, SKAP55, and SKAP-HOM for integrin and NF-κB signaling in T cells. J Clinical & Cellular Immunology. S12
  Witte A, J Degen, K Baumgart, N Waldt, B Kuropka, C Freund, B Schraven, S Kliche
  
• 2012. Induktion von Apoptose und Signaltransduktion in leukämischen Zellen unter Tyrosinkinase-Inhibitor-Behandlung
  Wagner, MC
  
• 2012. Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells. PLoS One. 7: e40853
  Lipka DB, MC Wagner, M Dziadosz, T Schnöder, F Heidel, M Schemionek, JV Melo, T Kindler, C Müller-Tidow, S Koschmeider, T Fischer
  (See online at https://doi.org/10.1371/journal.pone.0040853)
• 2012. Pick your poison: the Ripoptosome, a cell death platform regulating apoptosis and necroptosis. Cell Cycle. 11: 460-407
  Feoktistova M, P Geserick, D Panayotova-Dimitrova, M Leverkus
  
• 2012. Specific phosphorylation of αA-crystallin is required for the αA-crystallininduced protection of astrocytes against staurosporine and C2-ceramide toxicity. Neurochem Int. 60: 652-658
  Li R, Z Zhu, G Reiser
  (See online at https://doi.org/10.1016/j.neuint.2012.02.031)
• 2012. TCR- mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells. EMBO Rep. 13: 386-391
  Warnecke N, M Poltorak, BS Kowtharapu, B Arndt, JC Stone, B Schraven, L Simeoni
  (See online at https://doi.org/10.1038/embor.2012.17)
• 2013. Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation. J Immunol Methods. 387: 276-283
  Arndt B, M Poltorak, BS Kowtharapu, P Reichardt, L Philipsen, JA Lindquist, B Schraven, L Simeoni
  (See online at https://doi.org/10.1016/j.jim.2012.11.006)
• 2013. Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-κB- and STAT1-dependent chemokine production in astrocytes. Acta Neuropathol. 126: 711-724
  Wang X, M Deckert, NT Xuan, G Nishanth, S Just, A Waisman, M Naumann, D Schlüter
  (See online at https://doi.org/10.1007/s00401-013-1183-9)
• 2013. Astrocytic Fas ligand expression is required to induce T-cell apoptosis and recovery from experimental autoimmune encephalomyelitis. Eur J Immunol. 43: 115-124
  Wang X, F Haroon, S Karray, M Deckert, D Schlüter
  (See online at https://doi.org/10.1002/eji.201242679)
• 2013. Cell death in the skin: how to study its quality and quantity? Methods Mol Biol. 961: 201-218
  Makarov R, P Geserick, M Feoktistova, M Leverkus
  
• 2013. cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis. Cell Rep. 5: 397-408
  Panayotova-Dimitrova D, M Feoktistova, M Ploesser, B Kellert, M Hupe, S Horn, R Makarov, F Jensen, S Porubsky, A Schmieder, AC Zenclussen, A Marx, A Kerstan, P Geserick, YW He, M Leverkus
  (See online at https://doi.org/10.1016/j.celrep.2013.09.035)
• 2013. Crystal structure and versatile functional roles of the COP9-signalosome subunit 1. Proc Natl Acad Sci USA. 110:11845-11850
  Lee JH, L Yi, J Li, K Schweitzer, M Borgmann, M Naumann, H Wu
  
• 2013. CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production. PLoS Pathog. 9:e1003455
  Nishanth G, M Deckert, K Wex, R Massoumi, K Schweitzer, M Naumann, D Schlüter
  (See online at https://doi.org/10.1371/journal.ppat.1003455)
• 2013. Embryonic stem cells stably expressing BDNF-GFP exhibit a BDNF-release-dependent enhancement of neuronal differentiation. J Cell Sci. 126: 5062-5073
  Leschik J, R Eckenstaler, K Nieweg, Lichtenecker P, Brigadski T, Gottmann K, Leßmann V, Lutz B
  (See online at https://doi.org/10.1242/jcs.135384)
• 2013. Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus. Cell. 152:1119-1133
  Karpova A, M Mikhaylova, S Bera, J Bär, PP Reddy, T Behnisch, V Rankovic, C Spilker, P Bethge, J Sahin, R Kaushik, W Zuschratter, T Kähne, M Naumann, ED Gundelfinger, MR Kreutz
  (See online at https://doi.org/10.1016/j.cell.2013.02.002)
• 2013. Fas/CD95-induced chemokines can serve as "find-me" signals for apoptotic cells. Mol Cell. 6: 1034-1048
  Cullen SP, CM Henry, CJ Kearney, SE Logue, M Feoktistova, GA Tynan, EC Lavelle, M Leverkus, SJ Martin
  (See online at https://doi.org/10.1016/j.molcel.2013.01.025)
• 2013. Helicobacter pylori induces type 4 secretion system-dependent, but CagA-independent activation of IκBs and NF- κB/RelA at early time points. Int J Med Microbiol. 303: 548-552
  Sokolova O, M Borgmann, C Rieke, K Schweitzer, HJ Rothkötter, M Naumann
  (See online at https://doi.org/10.1016/j.ijmm.2013.07.008)
• 2013. Molecular mechanisms driving homeostatic plasticity of neurotransmitter release. Front Cell Neurosci. 7:244
  Lazarevic V, S Pothula, M Andres-Alonso, A Fejtova
  (See online at https://doi.org/10.3389/fncel.2013.00244)
• 2013. Nilotinib shows prolonged intracellular accumulation upon pulse-exposure: a novel mechanism for induction of apoptosis in CML cells. Leukemia. 27: 1567-1570
  Wagner MC, M Dziadosz, JV Melo, F Heidel, T Fischer, DB Lipka
  
• 2013. PAR-1 activation rescues astrocytes through the PI3K/Akt signaling pathway from chemically induced apoptosis that is exacerbated by gene silencing of β-arrestin 1. Neurochem Int. 67: 46-56
  Zhu Z, G Reiser
  (See online at https://doi.org/10.1016/j.neuint.2013.12.007)
• 2013. Regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κB) by protein Kinase C theta (PKC-θ) and cylindromatosis (CYLD) in murine listeriaosis and toxoplasmosis
  Nishanth, G
  
• 2013. Regulation of presynaptic anchoring of the scaffold protein Bassoon by phosphorylation-dependent interaction with 14-3-3 adaptor proteins. PLoS One. 8: e58814
  Schröder MS, A Stellmacher, S Romorini, C Marini, C Montenegro-Venegas, WD Altrock, ED Gundelfinger, A Fejtova
  (See online at https://doi.org/10.1371/journal.pone.0058814)
• 2013. T cell activation results in conformational changes in the SRC family kinase lck to induce its activation. Sci Signal. 6: ra13
  Stirnweiss A, R Hartig, S Gieseler, JA Lindquist, P Reichardt, L Philipsen, L Simeoni, M Poltorak, C Merten, W Zuschratter, Y Prokazov, W Paster, H Stockinger, T Harder, M Gunzer, B Schraven
  (See online at https://doi.org/10.1126/scisignal.2003607)
• 2013. TCR activation kinetics and feedback regulation in primary human T cells. Cell Commun Signal. 11: 4
  Poltorak M, B Arndt, BS Kowtharapu, AV Reddycherla, V Witte, JA Lindquist, B Schraven, L Simeoni
  (See online at https://doi.org/10.1186/1478-811X-11-4)
• 2013. The ubiquitin ligase Praja1 reduces NRAGE expression and inhibits neuronal differentiation of PC12 cells. PLoS One. 8: e63067
  Teuber J, B Mueller, R Fukabori, D Lang, A Albrecht, O Stork
  (See online at https://doi.org/10.1371/journal.pone.0063067)
• 2014. Analysis of nuclear functions of the synapto-nuclear messenger Jacob
  Kaushik, R
  
• 2014. Analysis of the TCR-mediated signaling dynamics
  Poltorak, M
  
• 2014. Bassoon specifically controls presynaptic P/Q-type Ca2+ channels via RIM-Binding protein. Neuron. 82:181-94
  Davydova D, C Marini, C King, J Klueva, F Bischof, S Romorini, C Montenegro-Venegas, M Heine, R Schneider, MS Schröder, WD Altrock, C Henneberger, DA Rusakov, ED Gundelfinger, A Fejtova
  (See online at https://doi.org/10.1016/j.neuron.2014.02.012)
• 2014. Biologische Charakterisierung von unterschiedlichen FLT3 internen Tandemduplikationen (ITD) in der akuten myeloischen Leukämie
  Mack, TS
  
• 2014. Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function. Haematologica. 99: e90-93
  Wolleschak D, TS Mack, F Perner, S Frey, TM Schnöder, MC Wagner, C Höding, MC Pils, A Parkner, S Kliche, B Schraven, K Hebel, M Brunner-Weinzierl, S Ranjan, B Isermann, DB Lipka, T Fischer, FH Heidel
  (See online at https://doi.org/10.1038/s41598-018-21839-3)
• 2014. Functional studies of β-arresting and αB-crystallin as interaction partners of PAR-1 and PAR-2 and their involvement in protective and proliferative signaling pathways in astrocytes
  Zhu, Z
  
• 2014. Glutamic acid decarboxylase 67 haplodeficiency impairs social behavior in mice. Genes, Brain, Behavior 13:439-450
  Sandhu KV, D Lang, B Muller, S Nullmeier, Y Yanagawa, H Schwegler, O Stork
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