Project Details
Projekt
Translocation mechanism of ABC exporters and the peptide-loading complex (P16)
Subject Area
Biochemistry
Term
from 2008 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 57566863
The transporter associated with antigen processing (TAP) is a focal point in adaptive immunity against infected or malignantly transformed cells. This ABC transporter shuttles proteasomal degradation products into the endoplasmic reticulum for loading onto major histocompatibility complex class-I molecules (MHC-I). The peptide-loading complex (PLC) orchestrates the peptide translocation, editing, and transfer to MHC-I molecules. We aim at investigating the translocation mechanism, conformational states, and their dynamics of TAP, related ABC transporters and the PLC using integrative structural and functional approaches.
DFG Programme
Collaborative Research Centres
Applicant Institution
Goethe-Universität Frankfurt am Main
Project Head
Professor Dr. Robert Tampé
