Project Details
Projekt
SFunction, subunit composition, and structure of archaeal ATP synthases (P14)
Subject Area
Biochemistry
Term
from 2008 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 57566863
Some archaeal ATP synthases have a double hairpin c subunit with only one ion binding site that, by current hypothesis, would prohibit ATP synthesis. We will unravel the physiological consequence of the unusual rotor and the molecular basis of ATP synthesis in enzymes purified from hyperthermophilic archaea and a mesophilic bacterium. Our project aims to (i) determine whether these species have lower phosphorylation potential, (ii) proof and energetically characterize ATP synthesis, (iii) determine the structure of the ATP synthases with a special focus on the c ring, and (iv) prove structure/function predictions by mutational analyses.
DFG Programme
Collaborative Research Centres
Applicant Institution
Goethe-Universität Frankfurt am Main
Project Head
Professor Dr. Volker Müller
