Mechanisms of synaptic plasticity during cortex-dependent learning (B09)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2008 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 36555331

The project deals mainly with cortex-dependent auditory discrimination learning in rodents that is also part of the integrative paradigm. Based on our previous findings we will address the following questions: (i) What is the role of phospholipase Cß signalling in the formation/consolidation of late memories? (ii) What is the role of bassoon-mediated presynaptic plasticity in learning and memory? (iii) What brain region- and cell type-specific changes in synaptic proteomes occur during memory formation? In particular, what are the molecular mechanistic differences between aversively and appetitively reinforced learning and memory processes?

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 779: Neurobiology of Motivated Behaviour
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Co-Applicant Institution: Leibniz-Institut für Neurobiologie (LIN)
• Project Heads: Professorin Dr. Daniela C. Dieterich; Professor Dr. Eckart D. Gundelfinger; Dr. Wolfgang Tischmeyer