Database-independent parallel screening for multiple post-translational protein modifications based on the modification-specific peptide fragmentation pathways

• Applicant: Dr. Marina Edelson-Averbukh, Ph.D.
• Subject Area: Biochemistry
• Term: from 2008 to 2010
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 63628683

• Final Report Year: 2011

Final Report Abstract

In this work the basis for the innovative screening of protein phosphor- and sulfotyrosinecontaining peptides has been created. The discovered reported ions of covalently modified peptides are now available for processing by bioinformatics tools.

Publications

• “Gas-phase intramolecular phosphate shift in phosphotyrosine-containing peptide monoanions”. Anal Chem. 2009, 81, 4369-81
  Edelson-Averbukh, M.; Shevchenko, A.; Pipkorn, R.; Lehmann, W.D.