The role of innate immune receptors in neurodegeneration (A01)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: from 2008 to 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 29837756

The project will investigate the role of human endogenous retrovirus RNA as an activator of innate immune receptors in different mouse models of CNS injury including sterile meningitis and a model of axonal degeneration, as well as on postmortem brain tissue of patients with Alzheimer´s disease. This project is based on the assumption that - besides infectious ligands of innate immune receptors such as Toll-like receptors (TLRs) - endogenous ligands derived from CNS cells can induce both innate immune actions and cell-autonomous neurodegeneration

• DFG Programme: CRC/Transregios
• Subproject of: TRR 43: The Brain as a Target of Inflammatory Processes
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Head: Professorin Dr. Seija Lehnardt