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Modeling of the transfer of adoptive immunity to hepatitis B and C virus in liver transplantation

Subject Area General and Visceral Surgery
Term from 2008 to 2011
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 5397027
 
Final Report Year 2012

Final Report Abstract

We successfully generated an HCV-prototype vaccine based on HBV capsid-like particles presenting mimotopes of the HCV E2-envelope protein. These HCV-CLPs were highly immunogenic in mice and the induced antibodies had great potential in cross-neutralizing different HCV strains including patient isolates. This prototype vaccine now permits the analysis of adoptive immune transfer in HCV-related liver transplantation.

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