Spinning Disc Super Resolution Confocal Microscope for Subcellular Live Cell Imaging

• Subject Area: Medicine
• Term: Funded in 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 549881107

The research focus of the applying groups is in the area of ion homeostasis, intracellularly mediated signaling molecules, and absorption and transport of drugs. The requested Spinning Disc Super Resolution combines the techniques of spinning disc confocal microscopy with super-resolution microscopy to generate detailed images of subcellular structures in living cells. This type of microscopy is particularly important for understanding dynamic processes at high temporal resolution on a cellular level that are not visible in conventional light microscopy. The rotation of the spinning disc allows for rapid live cell imaging to observe subcellular structures and signaling pathways in living cells in real time. This is crucial for investigating structures and processes in cells at a molecular level and with high temporal resolution. The Spinning Disc Super Resolution confocal microscope is a powerful tool in the life sciences. This technology helps us to understand fundamental processes in cells and contributes to the development of new therapeutic approaches. The device will be installed in the Center of Drug Absorption and Transport (C_DAT) building at the University of Greifswald, enhancing the research capabilities of the participating groups.

• DFG Programme: Major Research Instrumentation
• Major Instrumentation: Spinning Disc Super Resolution Konfokalmikroskop für subzelluläres Live Cell Imaging
• Instrumentation Group: 5090 Spezialmikroskope
• Applicant Institution: Universität Greifswald
• Leader: Professor Dr. Maik Gollasch