Role of RAGE signalling in peripheral nerve regeneration and in mediating the neurotrophic effects of the HNK-1 carbohydrate

• Applicant: Professorin Dr. Melitta Schachner
• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2007 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 54924842

• Final Report Year: 2014

Final Report Abstract

We were able to address several functional and structural aspects of sulfated glycans in development and regeneration of the nervous system in several publications related to the HNK-1 family of sulfotransferases. With sulfation being an important epitope in cell functions, we hope that our contribution to this topic will be accepted as satisfactory.

Publications

• (2011) Dermatansulfotransferase Chst14/D4st1, but not chondroitin sulfotransferase Chst11/C4st1, regulates proliferation and neurogenesis of neural progenitor cells. J. Cell Sci. 2011 124(Pt 23):4051-4063
  Bian S, Akyüz N, Bernreuther C, Loers G, Laczynska E, Jakovcevski I, Schachner M
  
• (2011) Glycomimetic improves recovery after femoral injury in a non-human primate. J. Neurotrauma 28: 1295-1306
  Irintchev A, Wu MM, Lee HJ, Zhu H, Feng YP, Liu YS, Bernreuther C, Loers G, You SW, Schachner M
  
• (2012) The effect of glycomimetic functionalized collagen on peripheral nerve repair. Biomaterials 33: 8353-8362
  Masand SN, Chen J, Perron IJ, Hammerling BC, Loers G, Schachner M, Shreiber DI
  
• (2013) Dermatan 4-O-sulfotransferase1 ablation accelerates peripheral nerve regeneration. Exp. Neurol. 247:517-530
  Akyüz N, Rost S, Mehanna A, Bian S, Loers G, Oezen I, Mishra B, Hoffmann K, Guseva D, Laczynska E, Irintchev A, Jakovcevski I, Schachner M