Neuronal NAADP signalling during neuroinflammation

• Applicants: Professor Dr. Marc Freichel; Professor Dr. Andreas H. Guse
• Subject Area: Molecular and Cellular Neurology and Neuropathology ; Pharmacology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 523862973

NAADP is the most potent Ca2+ releasing second messenger known today. Among many other cell types, NAADP also operates in neurons. We hypothesize that NAADP signalling is required for oscillatory Ca2+ signalling and survival during physiological glutamate stimulation, but contributes to neuronal Ca2+ overload and cell death during excitotoxic glutamate stimulation. We will analyse how NAADP receptors and NAADP generating enzymes shape NAADP evoked Ca2+ signalling in neurons, modulate neuroprotection vs neurodegeneration in vitro as well as in mouse models for multiple sclerosis in vivo.

• DFG Programme: Research Units
• Subproject of: FOR 5705: NeuroFlame – Defence and demise of inflamed neurons