Project Details
Projekt
Axonal transport and presynaptic function during neuroinflammation
Subject Area
Molecular and Cellular Neurology and Neuropathology
Term
since 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 523862973
Neuroinflammation impairs neuronal homeostasis and viability through a number of pathophysiological processes, including axonal transport regulating presynaptic function. The proposed project aims to (i) gain functional insights into inflammation-induced changes in microtubule dynamics, (ii) investigate their contribution to axonal transport deficits and/or synaptic dysfunction under inflammatory triggers, and (iii) explore neuronal defense strategies to combat such pathological changes. Using neuronal live-cell imaging, proximity labeling-based identification of the presynaptic proteome and EAE in vivo, we aim to investigate and rescue axonal and synaptic pathomechanisms under inflammatory conditions.
DFG Programme
Research Units
