SFB 566:  Cytokine Receptors and Cytokine-Dependent Signal Paths as Therapeutic Target Structures

• Subject Area: Medicine
• Term: from 2001 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5484359

The collaborative research centre has put the main emphasis on identifying cytokine receptors and cytokine receptor-dependent intracellular signalling molecules as a target for the therapeutical influence of cytokines. The scientific program includes projects on one of the most exiting areas within cytokine research. The short- and medium-term aims include the identification of receptor molecules and signalling peptides as targets for both, positive or negative therapeutic influences of cytokine effects by either natural peptides or chemically produced specific inhibitors. In the long-term the clinical use of the identified inhibitors or stimulators of hematopoiesis is planned in different disorders of e.g. hematopoiesis, malignancies, immunology and defense of infections. As an example for a promising outcome of this therapeutic strategy the successful inhibition of the abl-specific tyrosine kinases in vivo in patients with Philadelphia-chromosome positive CML could be mentioned.

• DFG Programme: Collaborative Research Centres

Completed projects

• A02 - Chemokine und Chemokinrezeptoren bei der HIV-1-Infektion (Project Heads Heiken, Hans ;  Schmidt, Reinhold Ernst )
• A04 - Cytokines as regulators of the biologic efffects of anaphylatoxins (Project Head Klos, Andreas )
• A05 - The role of TPO and MPL in congenital disorders of hematpoiesis (Project Heads Ballmaier, Matthias ;  Welte, Karl )
• A06 - The impact of IL-12 family cytokines on keratinocyte T cell interaction in eczema (Project Heads Werfel, Thomas ;  Wittmann, Miriam )
• A07 - Die rolle von Interferon ß bei der Immunantwort gegen Krankheitserreger und der Aufrechterhaltung des immunologishen Gedächtnis (Project Head Weiß, Siegfried )
• A08 - Bedeutung von genetishen Differenzen in der Zytokinexpression für Krankheitsdispositionen (Project Heads Hundrieser, Joachim ;  Wonigeit, Kurt )
• A10 - mRNA stabilization through the p38 MAP kinase pathway: identification and functional characterization of proteins involved (Project Head Holtmann, Helmut )
• A11 - Die Rolle von oligodendroglialen Chemokinrezeptoren bei der Myelinisierung und Remyelinisierung (Project Heads Brück, Wolfgang ;  Stangel, Martin )
• A12 - Small regulatory RNAs and target identification in chronic myeloid leukemia (CML) (Project Heads Eder, Matthias ;  Scherr, Michaela )
• A13 - Rolle von TGFß in der Th2-dominierten entzündung: Regulation von Eosinophilen- und Mastzellfunktionen (Project Head Bischoff, Stephan )
• A14 - The influence of sphingosin-1-phosphate on immune cell migration under phyiological conditions and autoreactive immune responses (Project Heads Förster, Reinhold ;  Pabst, Oliver )
• A15 - The role of IFN-beta in inflammatory diseases: EAE as a model system (Project Head Weiß, Siegfried )
• A16 - Expression of the Mpl receptor for the regeneration of hematopoietic stem cells and megakaryopoiesis (Project Heads Baum, Christopher ;  Meyer, Johann ;  Modlich, Ph.D., Ute )
• B01 - G-CSF-vermittelte Signaltransduktion in myeloischen Zellen von Patienten mit schwerer kongenitaler Neutropenie im Vergleich zu gesunden Kontrollpersonen (Project Head Welte, Karl )
• B02 - Signal transduction pathways of c-Kit and its related kinases: mRNA export and hematopoiesis (Project Heads Mancini, Annalisa ;  Tamura-Niemann, Teruko )
• B04 - Regulation des potentiellen Tumorsuppressorgens mad 1 durch Zytokine (Project Head Lüscher, Bernhard )
• B05 - Regulation des Interleukin-1 Rezeptorsystems: Entwicklung neuer pharmakologischer Interventionsmöglichkeiten durch Antagonisten auf Ebene der IL-1 Rezeptoren und der initialen Signaltransduktion (Project Head Martin, Michael Uwe )
• B06 - Beeinflussung der Wirkungen pro-inflammatorischer Zytokine durch gentechnische Manipulation von MAP Kinasekaskaden in vitro und in vivo (Project Head Kracht, Michael )
• B07 - Antiviral and antitumoral mechanisms of IRF-1 activity (Project Heads Hauser, Hansjörg ;  Kröger, Andrea )
• B08 - Bedeutung IL6/gpl30-abhängiger Signalkaskaden für die Leber (Project Head Trautwein, Christian )
• B09 - gp130-dependent acute phase reaction: new therapeutical strategies to prevent vascular diseases (Project Heads Drexler, Helmut ;  Schieffer, Bernhard )
• B11 - The role of the KSHV/HHV8 K15 protein in the activation of inflammatory cytokines and the NFkB pathway (Project Head Schulz, Thomas )
• B12 - MAPKAP kinase 2 (MK2) in inflammation: Molecular mechanisms and potential target for therapy (Project Heads Gaestel, Matthias ;  Kotlyarov, Alexey )
• B13 - Modulation of cytokine expression and cytokin mediated expression (Project Heads Frank, Ronald ;  Nourbakhsh, Mahtab )
• B14 - The Role of growth-differentiation factor-15 and tAB1 after myocardial infarction:Upstream regulators, interaction partners, annd downstream targets (Project Head Wollert, Kai Christoph )
• B15 - The Role of the endosomal adapter molecule p14 in cytokine-receptor signal transduction and hematopoiesis (Project Head Klein, Christoph )
• B16 - Role of Protein Kinase C (PKC) - isoforms on TGF-ß/ glucose mediated podocyte signaling and apoptosis (Project Heads Haller, Hermann ;  Schiffer, Mario )
• B17 - Molecular causes and functional consequences of TNF tolerance (Project Head Brand, Korbinian )
• Z01 - Zentrale Aufgaben (Project Head Welte, Karl )
• Z02 - Identification of differentially expressed genes by DNA microarrays (Project Heads Gaestel, Matthias ;  Kracht, Michael )

• Applicant Institution: Medizinische Hochschule Hannover
• Participating Institution: Helmholtz-Zentrum für Infektionsforschung (HZI)
• Spokesperson: Professor Dr. Karl Welte