SFB 530:  Spatio-Temporal Interactions of Cellular Signalling Molecules

• Subject Area: Biology ; Medicine
• Term: from 1999 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5483434

The collaborative research centre investigates interactions of cellular signal molecules (Ca and proteins) with high resolution using emerging imaging technology together with biochemical, biophysical and transgenic approaches. The research projects focus on elementary processes such as protein transport, ionic currents, and the release of neurotransmitters. In a concerted approach, signal molecules, their interactions and the processes resulting from these interactions will be integrated to understand cell functions including secretion, activation mechanisms of immune competent cells, and synaptic transmission.

• DFG Programme: Collaborative Research Centres

Completed projects

• A01 - Subunits of Ca 2+-selective cation channels (Project Head Flockerzi, Veit )
• A2 - Mechanismen der Aufnahme und Freisetzung von Va2+ in zentralen Neuronen (Project Heads Garaschuk, Olga ;  Konnerth, Arthur )
• A03 - Subcellular analysis of T-cell activation (Project Head Hoth, Markus )
• A04 - Funktion von TRPC4- und TRPM3-Kanälen in der Maus (Project Heads Cavalié, Adolfo ;  Philipp, Stephan E. )
• A05 - Regulation von Ca2+ Einstromwegen in elektrisch nicht-erregbaren Zelltypen (Project Heads Krause, Elmar ;  Schulz-Hofer, Irene )
• A06 - Deletion and analysis of the function of calcium channels in mice (Project Head Freichel, Marc )
• A07 - Molecular Mechanisms of Pheromone Detection (Project Head Zufall, Frank )
• B01 - Calcium signals and transmitter release in glial cells (Project Head Deitmer, Joachim W. )
• B2 - Ca2+ - und Na+ - abhängige Transduktions-Signale und synaptische Aktivität der Rezeptorzellen des Geschmacks (Project Head Lindemann, Bernd )
• B3 - Dendritische Signalintegration in Purkinje Neuronen des Kleinhirns (Project Heads Eilers, Jens-Karl ;  Konnerth, Arthur )
• B5 - Ontogenese des auditorischen Systems von Säugern: Signalmoleküle bei der Reifung inhibitorischer und exzitatorischer Verbindungen (Project Head Friauf, Eckhard )
• B6 - Die Rolle von Inositol 1,4,5-trisphosphat mobilisierenden Hormonen für die kardiale Erregungs-Kontraktions Kopplung (Project Head Lipp, Ph.D., Peter )
• B06 - InsP3-mobilising hormones and cardiac function: the role of protein kinases C (Project Head Lipp, Ph.D., Peter )
• C01 - Signal peptide-dependent protein transport from the cytosol inti the ER: mechanisms, dynamics and pathology of protein translocase (Project Head Zimmermann, Richard )
• C03 - Exchange of Macromolecules between the Cell Nucleus and the Cytoplasm (Project Head Schlenstedt, Gabriel )
• C5 - Zeitabhängige Änderungen in der Neurotrophin-vermittelten Genexpression (Project Head Thiel, Gerald )
• C6 - Differentieller Einfluß neurotropher Faktoren auf corticospinale Neurone (Project Head Giehl, Klaus )
• C8 - Zeitliche und räumliche Interaktionen von TGF-ß- und GDNF-abhängigen Signalen in der Regulation von Nervenzell-Überleben (Project Head Krieglstein, Kerstin )
• C09 - Molecular Mechanisms of Neurotransmitter Release (Project Head Rettig, Jens )
• C10 - Molecular mechanisms of exocytosis (Project Head Bruns, Dieter )
• C11 - Molecular and functional characterization of ribbon pses from the retina (Project Head Schmitz, Frank )
• C12 - Role of second messengers in the regulation of chromaffin cells secretion (Project Head Becherer, Ph.D., Ute )
• C13 - Strukturelle Charakterisierung von Rab4-abhängigen Regulatoren des vesikulären Transports (Project Head Scheidig, Axel J. )
• C14 - Biological functions of Egr-1 in the nervous system (Project Head Thiel, Gerald )
• C15 - Mitochondrial protein insertion by the OXA1 machinery (Project Head Herrmann, Johannes M. )
• D01 - Proteinchemie und Antikörper (Project Heads Jung, Martin ;  Zimmermann, Richard )
• D2 - Definierte Mutanten (Project Head Flockerzi, Veit )
• Z - Zentrales Verwaltungsprojekt (Project Head Flockerzi, Veit )

• Applicant Institution: Universität des Saarlandes
• Participating University: Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau
• Spokesperson: Professor Dr. Veit Flockerzi