The interplay of mitochondrial ribosomes and the quality control machinery during ribosome rescue (P19#)

• Subject Area: General Genetics and Functional Genome Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 469281184

Mitochondria contain a unique translation machinery, which consists of the mitochondrial ribosome (mitoribosome) and specialized translation factors. Defects in mitochondrial translation such as mitoribosome stalling lead to a decline in cellular energy production associated with severe human diseases. To resolve stalled mitoribosome complexes, specific rescue systems are required, which are still ill defined in human mitochondria. Here, we aim to decipher the molecular machineries and mechanisms of rescuing mitoribosomes stalled under distinct conditions, and to dissect the interplay between the mitoribosome and the quality control machinery that prevents proteotoxic stress.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1565: Molecular mechanisms and interplay of gene expression processes
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professorin Dr. Ricarda Richter-Dennerlein