Project Details
Projekt
Membrane remodelling driven by SARS-CoV-2 proteins (P03)
Subject Area
Biophysics
Term
since 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 511488495
This project will focus on the membrane remodeling that is critical for the assembly and replication of the SARS-CoV-2 virus. We hypothesize that SARS-CoV-2 assembly involves membrane bending induced by both viral transmembrane proteins and adhesion of biomolecular condensates formed by viral ribonucleoprotein. We will use in situ cryo-electron tomography to study virus assembly and replication vesicles composed of different sets of viral proteins. This will be combined with mathematical continuum models to achieve a quantitative understanding of the interplay between membrane bending by proteins and by adhesion of biomolecular condensates. In the long term, this approach will provide a better understanding of the complex membrane remodeling processes occurring during viral infections.
DFG Programme
Collaborative Research Centres
Applicant Institution
Ruprecht-Karls-Universität Heidelberg
Project Heads
Dr. Petr Chlanda; Professor Dr. Ulrich Schwarz
