Impact of chronobiologic modulation on behavioural rhythms, neuroplasticity and immune-metabolic parameters (B08)

• Subject Area: Biological Psychiatry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 521379614

Disturbed cognitive-behavioural rhythms frequently precede depressive episodes in patients. In project B08, we investigate the impact of circadian rhythm disruption in mice on transition to depressive behaviour, alterations in EEG/sleep rhythm and molecular and cellular readouts of circadian gene expression, neuroplasticity and immune metabolism in brain tissue and in the peripheral blood. This project aims to expose novel neurobiological signatures predictive for behavioural changes of concomitant depression-like behavioural alterations in animals, resembling disease trajectories in human patients.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 393: Trajectories of Affective Disorders: Cognitive-emotional Mechanisms of Symptom Change
• Applicant Institution: Philipps-Universität Marburg
• Project Heads: Professor Dr. Carsten Culmsee; Privatdozent Dr. Kay Jüngling