Selective quantification of photoreceptors in retinal dystrophies using optical coherence tomography and artificial intelligence.

• Applicant: Dr. Leon von der Emde
• Subject Area: Ophthalmology ; Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 546727843

The research project focuses on the selective quantification of photoreceptors in retinal dystrophies using optical coherence tomography (OCT) and artificial intelligence. It investigates the distribution and density of rod and cone loss in the retina, which are essential for the understanding of retinal function and the diagnosis of retinal dystrophies. These diseases, often genetic, can lead to blindness in childhood. Traditional examination methods involve time-consuming psychophysical tests. The project therefore aims to use rapid, high-resolution OCT imaging to test differentiated visualization of rods and cones, which could identify new biomarkers for the diagnosis and monitoring of retinal dystrophies. This will be achieved with a new high-resolution OCT device that can image the rod and cone outer segment tips separately. The project involves correlating OCT data with AOSLO results and histologic examinations of donor tissue as well as linking OCT data with functional tests. The results could contribute to a deeper understanding of retinal dystrophies and the development of targeted treatment strategies.

• DFG Programme: Research Grants