The neuroanatomical underpinnings of clinical aggression and their relationship with the negative valence and cognitive control systems (C05)

• Subject Area: Biological Psychiatry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 512007073

C05 will link questionnaire measures of aggression to specific neural substrates using structural MRI. The resulting patterns of aggression-related neuroanatomical variability will be coregistered with the Allen Human Brain Atlas providing gene-expression data, to highlight genes with a spatial pattern of expression that matches the neuroimaging findings. Utilizing the neurotypical control data, a normative model of neuroanatomical diversity within the NVS and CS will be established to quantify neuroanatomical abnormalities within these systems in individual cases.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 379: Neuropsychobiology of Aggression: A Transdiagnostic Approach in Mental Disorders
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Head: Professorin Christine Ecker, Ph.D.