Project Details
Projekt
The metabolic lung-brain axis in aggressive behavior in patients with AMD (A08)
Subject Area
Biological Psychiatry
Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry
Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry
Term
since 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 512007073
Using MR spectroscopy. A08 aims to (1) identify whether acetone and other volatile organic compounds in breath are associated with aggression and acute threat processing in mental disorders and (2) to examine whether these breath markers are associated with direct metabolic brain correlates (like BHB, glutamate) and with the brain-derived neurotrophic factor (BDNF) levels in plasma. In a translational approach, (3) we will test if supplementation of BHB reduces aggressive behavior in mice.
DFG Programme
CRC/Transregios
Subproject of
TRR 379:
Neuropsychobiology of Aggression: A Transdiagnostic Approach in Mental Disorders
Applicant Institution
Rheinisch-Westfälische Technische Hochschule Aachen
