Discovery and targeting of ubiquitin-dependent synthetic vulnerabilities in NSCLC (A09)

• Subject Area: Human Genetics ; Hematology, Oncology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514894665

Project A09 will systematically map ubiquitin-dependent synthetic vulnerabilities in KRAS-driven non-small cell lung cancer (NSCLC). Building on own genetic technologies and disease model, the applicants will perform high-throughput CasRx screening to probe millions of genetic target combinations affecting cellular fitness and identity. The study aims to (i) identify synthetic dependencies within the UPS for the design of combinatorial therapies, (ii) map determinants of epithelial-mesenchymal plasticity to target plasticity-related chemotherapy resistance, and (iii) perform mechanistic and preclinical studies on new targets/target combinations.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 387: Functionalizing the Ubiquitin System against Cancer - UbiQancer
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professor Manuel Kaulich, Ph.D.; Professor Dr. Roland Rad