Impact of JAZ9 allelic variation on proteoform structure, JA-Ile co-receptor assembly and plant performance (B04)

• Subject Area: Plant Physiology ; Biochemistry ; Plant Biochemistry and Biophysics ; Biophysics ; Structural Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514901783

B04 explores JASMONATE-ZIM-DOMAIN PROTEIN 9 (JAZ9), a crucial negative regulator of JA signalling. JAZ proteins play key roles in fundamental developmental processes and environmental adaptation. They inhibit TFs governing JA responses, and in the presence of JA-Isoleucine, they bind to the E3 ubiquitin ligase complex, leading to their degradation and liberation of TFs initiating JA responses. B04 focuses on natural JAZ9 variants affecting interaction with target proteins and E3 ubiquitin ligase complex formation, examined through protein-protein interaction and stability assays.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1664: Plant Proteoform Diversity - SNP2Prot
• Applicant Institution: Martin-Luther-Universität Halle-Wittenberg
• Project Heads: Professor Dr. Jochen Balbach; Dr. Debora Gasperini