Allelic variation of a vacuolar cation channel modulating ion homeostasis and calcium signalling in plants (B03)

• Subject Area: Plant Physiology ; Biochemistry ; Plant Biochemistry and Biophysics ; Bioinformatics and Theoretical Biology ; Biophysics ; Evolution and Systematics of Plants and Fungi ; Plant Genetics and Genomics ; Structural Biology ; Plant Cell and Developmental Biology ; Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 514901783

B03 focuses on calcium signalling, specifically the TPC1 cation channel in the vacuole. The project aims to understand the proteoform-specific regulation by cytosolic calcium and phosphorylation, emphasising selectivity. Using imaging techniques, the impact of TPC1 proteoforms on Ca2+ signal generation, decoding, and information propagation to plant parts will be analysed. Using electrophysiology, phosphoproteomics and imaging, the project aims to reveal insights into how systemic regulatory components' natural variation aids adaptation to environmental stress.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1664: Plant Proteoform Diversity - SNP2Prot
• Applicant Institution: Martin-Luther-Universität Halle-Wittenberg
• Project Heads: Professor Dr. Edgar Peiter; Professorin Dr. Tina Romeis