Exploring ion minibeam radiation therapy

• Applicant: Professor Andrea Mairani, Ph.D.
• Subject Area: Nuclear Medicine, Radiotherapy, Radiobiology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 545524061

We propose to explore a novel radiotherapeutic approach, termed ions minibeam radiation therapy (IONSMBRT). This innovative approach combines the superior tumor eradication capabilities of ion radiotherapy with the exceptional tissue conservation attributes of Minibeam Radiation Therapy (MBRT). The unique combination of these features positions IONSMBRT as a transformative solution in enhancing patient care, particularly in the context of radioresistant and immunosuppressive tumors. For the first time, normal tissue response to IONSMBRT and its efficacy in tumor control will be investigated. Our investigation will extend to the response of both thoracic and abdominal regions to helium and carbon IONSMBRT. We will evaluate tumor control using a tumor model based on a cancer with especially poor prognosis in the clinic, such as pancreatic cancer. Our primary objective is to confirm or disprove the hypothesis that IONSMBRT can synergistically harness the physical characteristics and biological effects of ion therapy and MBRT towards its clinical application. We will accomplish this by studying the radiobiological response and mechanisms of action in vivo in murine models. Our research carries the potential to revolutionize the field of radiotherapy and pave the way for more effective cancer treatments.

• DFG Programme: Research Grants
• International Connection: France
• Partner Organisation: Agence Nationale de la Recherche / The French National Research Agency
• Co-Investigator: Ivana Dokic, Ph.D.
• Cooperation Partner: Professorin Yolanda Prezado, Ph.D.