Fertility in the Klinefelter syndrome by testicular stem cell transplantation - an experimantal approach in the XXY mice
Final Report Abstract
The findings of the project up to now are summarized below and compared with findings from KS patients: We found our mouse model • to carry a clear signal for the Y-chromosome adjacent to one X-chromosome • to be infertile • to exhibit small firm testes to be heavier than littermate and v/ild type controls • to lack germ cells after puberty • to exhibit hypergonadotrophic hypogonadism • to develop Leydig cell hyperplasia • to have an obviously disturbed androgenisation but not an impaired but hyper-activated Leydig cell function • to show deficits in the non-conditional memory and recognition tests • to reveal a methylation profile related to X-inactivation resembling closely the state of Klinefelter patients • to show a developmental time course of germ cell loss similar to what is reported for the majority of patients
Publications
- Männliche Mäuse mit einem überzähligen X-Chromosom (41 XXy*): Ein Model für XX-Männer? Joumal für Reproduktionsmedizin und Endokrinologie, 5,261,2007
Wistuba J, Gromoll J, Stukenborg JB, Damm 0, Hämäläinen T, Simoni M, Nieschlag E, Luetjens CM
- Männliche Mäuse miteinem überzähligen X-Chromosom (41 XXy*) Zeigen kognitive Einschränkungen bei der Objekterkennung. Joumal für Reproduktionsmedizin und Endokrinologie, 5,260,2007
Wistuba J, Damm o, Luetjens CM, Simoni M, Nieschlag E, Lewejohann L.
- Co-culture of spermatogonia w/ith somatic cells in a novel three-dimensional Soft-Agar-Culture-System. Joumal of Andrology 2008,29: 312-329
Stukenborg JB, Wistuba J, Luetjens CM, Huleihel M, Lunenfeld E, Gromoll J, Nieschlag E, Schlatt S.
- Cognitive disabilities in the novel object task of male mice canying a supemumerary X chromosome (41, XXy*). Endocrine Abstracts (2008)16OC5.9
Wistuba J, Damm OS, Luetjens CM, Simoni M, Nieschlag E, Lewejohann L
- Impaired recognition memory in male mice with a supemumerary X chromosome. Physiology and Behavior, 2008
Lewejohann L, Damm 0, Luetjens CM, Hämäläinen T, Simoni M, Nieschlag E, Gromoll J, Wistuba J.
- Leydig Cell function in 41 XXy* male mice. Intemational Journal of Andrology 31, Suppl 1, P12, 2008
Wistuba J, Luetjens CM, Nieschlag E, Dittmann E, Stukenborg JB, Simoni M, Gromoll J.
- Physiologie der Leydig Zellen männlicher Mäusen mit überzähligem X-Chromosom (Karyotyp 41, XXy*). Joumal für Reproduktionsmedizin und Endokrinologie 5 2008; 225
Wistuba J, Luetjens CM., Nieschlag E., Dittmann M., Stukenborg J.B., Simoni M. and Gromoll J.
