Maintaining gene expression fidelity in response to DNA- and RNA-protein crosslinks (A02)

• Subject Area: Biochemistry ; General Genetics and Functional Genome Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 520471345

Human cells are exposed to stressors that can induce DNA- and RNA-protein crosslinks, thus interfering with different steps of gene expression. The molecular determinants regulating transcription and pre-mRNA processing in the presence of crosslinks remain poorly understood. We will investigate the molecular components that ensure fidelity of gene expression in the presence of DNA- and RNA-protein crosslinks. We anticipate our work to provide new understanding of how a specific type of DNA and RNA damage affects faithful gene expression throughout the lifespan of cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1678: Systems-level consequences of fidelity changes in mRNA and protein biosynthesis
• Applicant Institution: Universität zu Köln
• Project Heads: Professorin Dr. Petra Beli; Professor Dr. Argyris Papantonis