Pharmakologische und physiologische Funktionen des Nikotinsäure-Rezeptors sowie verwandte G-Protein-gekoppelte Rezeptoren

• Applicant: Professor Dr. Stefan Offermanns
• Subject Area: Pharmacology
• Term: from 2004 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5442806

• Final Report Year: 2010

Final Report Abstract

No abstract available

Publications

• (2005) Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G). Mol Pharmacol 68, 1271-1280
  Tunaru S, Lattig J, Kero J, Krause G, Offermanns S
  
• (2005) GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J Clin Invest 115, 3634-3640
  Benyo Z, Gille A, Kero J, Csiky M, Suchankova MC, Nusing RM, Moers A, Pfeffer K, Offermanns S
  
• (2006) Nicotinic Acid-induced flushing is mediated by activation of epidermal langerhans cells. Mol Pharmacol 70, 1844-1849
  Benyo Z, Gille A, Bennett CL, Clausen BE, Offermanns S
  
• (2006) The nicotinic acid receptor GPR109A (HM74A/PUMA-G) as a new therapeutic target. Trends Pharmacol Sci 27, 384-390
  Offermanns S
  
• (2007) Nicotinic acid in lipid metabolism disorders. Pharm Unserer Zeit 36, 120-125
  Ahmed K, Offermanns S
  
• (2008) Nicotinic acid: an old drug with a promising future. Br J Pharmacol 153 Suppl 1, 68-75
  Bodor, ET, and Offermanns, S
  
• (2008) Nicotinic acid: Pharmacological effects and mechanisms of action. Annu Rev Pharmacol Toxicol 48, 79-106
  Gille A, Bodor ET, Ahmed K, Offermanns S
  
• (2009) Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis. J BiolChem. 284, 21928-33
  Ahmed K, Tunaru S, Langhans CD, Hanson J, Michalski CW, Kölker S, Jones PM, Okun JG, Offermanns S
  
• (2009) GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors. Trends Pharmacol Sci. 30, 557-562
  Ahmed K, Tunaru S, Offermanns S
  
• (2010) An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Cell Metab. 11, 311-19
  Ahmed, K., Tunaru, S., Tang, C., Müller, M., Gille, A., Sassmann, A., Hanson, J., and Offermanns, S
  
• (2010) Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J. Clin. Invest 120, 2910-2919
  Hanson J, Gille A, Zwykiel S, Lukasova M, Clausen BE, Ahmed K, Tunaru S, Wirth A, Offermanns S