Further analysis of MK5 deficient mice: Role of MK5/ERK3/4 signalling in tumor suppression and neuronal functions

• Applicant: Dr. Alexey Kotlyarov
• Subject Area: Cell Biology
• Term: from 2004 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5441674

• Final Report Year: 2016

Final Report Abstract

No abstract available

Publications

• (2010) MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin. Biochemical pharmacology 80: 1915-1920
  Ronkina N, Menon MB, Schwermann J, Tiedje C, Hitti E, Kotlyarov A, Gaestel M
  
• (2010) Molecular mechanisms of phosphorylation-regulated TTP (tristetraprolin) action and screening for further TTP-interacting proteins. Biochemical Society transactions 38: 1632-1637
  Tiedje C, Kotlyarov A, Gaestel M
  
• (2010) p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins. The Journal of biological chemistry 285: 33242-33251
  Menon MB, Schwermann J, Singh AK, Franz-Wachtel M, Pabst O, Seidler U, Omary MB, Kotlyarov A, Gaestel M
  
• (2011) Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3. The Journal of biological chemistry 286: 24113-24124
  Ehlting C, Ronkina N, Bohmer O, Albrecht U, Bode KA, Lang KS, Kotlyarov A, Radzioch D, Gaestel M, Haussinger D, Bode JG
  
• (2011) SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition. PloS one 6: e23054
  Menon MB, Kotlyarov A, Gaestel M
  
• (2011) Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes. Nucleic acids research 39: 2503-2518
  Ronkina N, Menon MB, Schwermann J, Arthur JS, Legault H, Telliez JB, Kayyali US, Nebreda AR, Kotlyarov A, Gaestel M
  
• (2012) Small-molecule protein and lipid kinase inhibitors in inflammation and specific models for their evaluation. Methods in molecular biology 795: 35-44
  Gaestel M, Kotlyarov A
  
• (2012) The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology. Molecular and cellular biology 32: 2467-2478
  Brand F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B, Britsch S, Meloche S, Gaestel M, Kotlyarov A
  (See online at https://doi.org/10.1128/MCB.06633-11)
• (2012) The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation. PLoS genetics 8: e1002977
  Tiedje C, Ronkina N, Tehrani M, Dhamija S, Laass K, Holtmann H, Kotlyarov A, Gaestel M
  (See online at https://doi.org/10.1371/journal.pgen.1002977)
• (2013) Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFalpha production. The Biochemical journal 456: 163-172
  Menon MB, Tiedje C, Lafera J, Ronkina N, Konen T, Kotlyarov A, Gaestel M
  (See online at https://doi.org/10.1042/BJ20130755)
• (2014) Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis. PLoS genetics 10: e1004558
  Menon MB, Sawada A, Chaturvedi A, Mishra P, Schuster-Gossler K, Galla M, Schambach A, Gossler A, Forster R, Heuser M, Kotlyarov A, Kinoshita M, Gaestel M
  (See online at https://doi.org/10.1371/journal.pgen.1004558)
• (2015) Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK. PloS one 10: e0136138
  Ronkina N, Johansen C, Bohlmann L, Lafera J, Menon MB, Tiedje C, Laass K, Turk BE, Iversen L, Kotlyarov A, Gaestel M
  (See online at https://doi.org/10.1371/journal.pone.0136138)
• (2015) p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex. Rna 21: 262-278
  Tiedje C, Lubas M, Tehrani M, Menon MB, Ronkina N, Rousseau S, Cohen P, Kotlyarov A, Gaestel M
  (See online at https://doi.org/10.1261/rna.048090.114)
• (2015) The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis. Journal of immunology 195: 541-552
  Soukup K, Halfmann A, Le Bras M, Sahin E, Vittori S, Poyer F, Schuh C, Luger R, Niederreiter B, Haider T, Stoiber D, Bluml S, Schabbauer G, Kotlyarov A, Gaestel M, Felzmann T, Dohnal AM
  (See online at https://doi.org/10.4049/jimmunol.1401663)
• (2015) The problem of pyridinyl imidazole class inhibitors of MAPK14/p38alpha and MAPK11/p38beta in autophagy research. Autophagy 11: 1425- 1427
  Menon MB, Dhamija S, Kotlyarov A, Gaestel M
  (See online at https://doi.org/10.1080/15548627.2015.1059562)
• (2016) GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis. Scientific reports 6: 20007
  Abbey M, Hakim C, Anand R, Lafera J, Schambach A, Kispert A, Taft MH, Kaever V, Kotlyarov A, Gaestel M, Menon MB
  (See online at https://doi.org/10.1038/srep20007)