Project Details
Maintenance and modification of epigenetic information: Coordination of DNA replication and methylation during the cell cycle and in development
Applicant
Professor Dr. Heinrich Leonhardt
Subject Area
Cell Biology
Term
from 2004 to 2012
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5437638
Final Report Year
2009
Final Report Abstract
No abstract available
Publications
- (2004). Replication independent chromatin loading of Dnmt1 during G2 and M phases. EMBO Rep., 5: 1181- 1186
Easwaran, H. P., Schermelleh, L., Leonhardt, H. and Cardoso, M. C.
- (2005) Restricted mobility of Dnmt1 in early embryos: implications for epigenetic reprogramming. BMC Dev. Biol., 5: 18
Grohmann, M., Spada, F., Schermelleh. L., Alenina, N., Bader, M., Cardoso, M. C. and Leonhardt, H.
- (2005). Cell cycle markers for live cell analyses. Cell Cycle, 4: 453-455
Easwaran, H. P., Leonhardt, H. and Cardoso, M. C.
- (2005). Recruitment of DNA methyltransferase I to DNA repair sites. PNAS. 102, 8905-8909
Mortusewicz, O., Schermelleh, L., Walter, J., Cardoso, M. C. and Leonhardt, H.
- (2009). DNA methylation-mediated epigenetic control. J. Cell. Biochem. (Epub ahead of print)
Rottach, A., Leonhardt, H. and Spada, F.
- 2005). Trapped in action - direct visualization of Dnmt1 activity in living cells. Nature Methods, 2, 751-756
Schermelleh, L., Spada, F., Easwaran, H. P., Zolghadr, K., Margot, J. B., Cardoso, M. C. and Leonhardt, H.
- (2006) Regulation of DNA methyltransferase 1. Adv. Enzym Regul., 46, 224-34
Spada, F., Rothbauer, U., Zolghadr, K., Schermelleh, L., Leonhardt, H.
- (2007). DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells. J. Cell Biol. 176, 565-71
Spada, F., Haemmer, A., Kuch, D., Rothbauer, U., Schermelleh, L., Kremmer, E., Carell, T., Längst, G. and H. Leonhardt
- (2007). Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation. Nucl. Acids Res. 35, 4301-12
Schermelleh, L., Haemmer, A., Spada, F., Rosing, N., Meilinger, D., Rothbauer, U., Cardoso, M. C. and H. Leonhardt
- (2008). A fluorescent two-hybrid (F2H) assay for direct visualization of protein interactions in living cells. Mol. Cell. Proteomics, 7, 2279-87
Zolghadr, K., Mortusewicz, O., Rothbauer, U., Kleinhans, R., Göhler, H., Wanker, E., Cardoso, M.C. and Leonhardt, H.
- (2008). Spatiotemporal dynamics of regulatory protein recruitment at DNA damage sites. J. Cell. Biochem., 104, 1562-9
Mortusewicz O, Leonhardt H. and Cardoso M.C.
- (2009) Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain. J. Cell. Biochem., 106, 521- 8
Fellinger, K., Rothbauer, U., Felle, M., Längst, G. and Leonhardt, H.
- (2009) MBD4 and MLH1 are required for apoptotic induction in xDnmt1-depleted embryos. Development, 136, 2277-86
Ruzov, A., Shorning, B., Mortusewicz, O., Dunican, D. S., Leonhardt, H., and Meehan, R.