Immunregulatorische Rolle nicht-klassischer MHC Moleküle in der Pathogenese der Multiplen Sklerose

• Applicant: Professor Dr. Heinz Wiendl
• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2004 to 2008
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5434017

• Final Report Year: 2008

Final Report Abstract

No abstract available

Publications

• Monocyte-derived HLA-G acts as a strong inhibitor of autologous CD4 T- cell activation and is upregutated by interferon-b in vitro and in vivo: rationale for the therapy of multiple sclerosis. J Neuroimmunol. 2005; 159:155-164
  Mitsdoerffer M, Schreiner B, Kieseier BC, Neuhaus O, Dichgans J, Hartung H-P, Weller M, Wiendl H
  
• xpression of the immunetolerogenic non-classical MHC molecule HLA-G in Multiple sclerosis: implications for CNS immunity. Brain. 2005;128(Pt 11):2689- 704
  Wiendl H, Feger U, Mittelbronn M, Jack C, Schreiner B, Meyermann R, Antel J, Kieseier BC, Weiler M
  
• Fast track to become a regulatory T cell: "trogocytosis" of immune-tolerogenic HLA-G. Blood. 2007; 109:1796-1797
  Wiendl H
  
• HLA-G expression defines a novel regulatory T cell subset present in human peripheral blood and sites of inflammation. Blood. 2007; 110(2);568-77
  Feger U, Tolosa E, Huang Y, Waschbisch A, Biedermann T, Melms A, Wiendl H
  
• HLA-G in the nervous system. Human Immunology. 2007; 68(4):286-93
  Wiendl H
  
• Immune-refractory cancers and their little helpers - an extended role for immune-tolerogenic MHC molecules HLA-G and HLA-E? Seminars in Cancer Biology. Semin Cancer Biol. 2007; 17(6}:459-468
  Wischhusen J, Waschbisch A, Wiendl H
  
• Postpartum-activation of multiple sclerosis associated with downregulation of tolerogenic HLA-G. J Neuroimmunol. 2007; 187(1-2):205-11
  Airas L, Nikula T, Huang Y, Lahesmaa R, Wiendl H
  
• The genetic influence of the nonclassical MHC molecule HLA-G on Multiple Sclerosis. Human Immunology. 2007; 68(5):422-5
  Kroner A, Grimm A, Johannssen K, Maeurer M, Wiendl H