Effekte der Langzeitapplikation des endogenen NO-Synthase-Inhibitors asymmetrisches Dimethylarginin (ADMA) auf Blutdruck, renale Hämodynamik und Organhistologie bei DDAH transgenen Mäusen

• Antragsteller: Privatdozent Dr. Jan Thomas Kielstein
• Fachliche Zuordnung: Nephrologie
• Förderung: Förderung von 2003 bis 2007
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5418119

• Erstellungsjahr: 2007

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Arginine Metabolism, Pulmonary Hypertension, and Sickle Cell Disease. JAMA 2005; 294: 2432-2432
  Kielstein JT, Cooke JP
  
• Asymmetyric Dimethylarginine: A cardiovascular risk factor and a uremic toxin coming of age? Am J Kidney Dis 2005; 46: 186-202
  Kielstein JT, Zoccali C
  
• Effects of Asymmetric dimethylarginine (ADMA) infusion in humans. Eur J Clin Pharmacol 2005; 14: 1-6
  Kielstein JT, Tsikas D, Fliser D
  
• Asymmetric dimethylarginine: a new player in the pathogenesis of renal disease? Curr Opin Nephrol Hypertens 2006; 15: 314-320
  Zoccali C, Kielstein JT
  
• Cigarettes and ADMA: The Smoke Hasn't Cleared Yet. Hypertension 2006; 177:2342-2346
  Kielstein JT, Peter C, Adams MC
  
• Symmetric dimethylarginine (SDMA) as endogenous marker of renal function—a meta-analysis. Nephrol Dial Transplant 2006; 21(9):2446-51
  Kielstein JT, Salpeter S, Bode-Böger SM, Cooke JP, Fliser D
  
• „Renal Function as a Predictor of Outcome in a Broad Spectrum of Patients With Heart Failure." Circulation 2006; 114: e242
  Kielstein JT, Cooke JP, Zoccali C
  
• "Highdose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid". Circulation. 2007; 8:115(18):e450-1
  Kielstein JT, Woywodt A, Salpeter SR
  
• A new perspective for the treatment of renal diseases? J Am Soc Nephrol 2007:18:1365-1367
  Kielstein JT, Zoccali C
  
• A novel bioluminescent tumor model of human renal cancer cell lines: an in vitro and in vivo characterization. J Urology. 2007; 177(6):2342-2346
  Peter C, Kielstein JT, Clarke-Katzenberg R, Adams MC, Pitsiouni M, Kambham N, Karimi MA, Kengatharan KM, Cooke JP
  
• Should we measure ADMA in patients with coronary artery disease? Clin Chem 2007; 53:161-163
  Kielstein JT, Cooke JP
  
• „Uremia". William C. Aird (Editor): "Endothelial Biomedicine" Harvard University, Massachusetts 2007 ISBN-13: 9780521853767
  Kielstein JT, Fliser D