Sesquiterpenoide und andere biologisch aktive Marker-Verbindungen in bulgarischen Achillea-millefolium-Arten

• Antragsteller: Professor Dr. Helmut Duddeck
• Fachliche Zuordnung: Organische Molekülchemie - Synthese, Charakterisierung
• Förderung: Förderung von 2003 bis 2006
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5409531

The purpose of this project is a comparative phytochemical study of the Bulgarian plant species of Achillea millefolium group (yarrow) used in folk medicine, with the view of identifying the main biologically active components and elucidating the structure of the unknown compounds. A special attention will be paid on the sesquiterpene lactones, as they are recognized to be the active principles in yarrow. The lactone-containing fractions will be submitted to separation using modern chromatographic techniques, and the individual compounds will be characterized by spectroscopic methods. The less polar fractions of the total plant extracts will be also investigated from both chemical and biological point of view. The plant species with the highest content of proazulenes and significant biological activity will be recommended for cultivation.

• DFG-Verfahren: Sachbeihilfen
• Internationaler Bezug: Bulgarien
• Beteiligte Personen: Privatdozentin Dr. Bozhana Mikhova; Privatdozentin Dr. Milka Nikolova Todorova