Chemisch-biologische Hybridverbindungen für die molekulare Organisation, Assemblierung und Manipulation von Proteinen

• Antragsteller: Professor Dr. Robert Tampé
• Fachliche Zuordnung: Biochemie
• Förderung: Förderung von 2003 bis 2011
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5469960

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2006) Controlling the activity of the 20S proteasome complex by synthetic gatekeepers. Ängew. Chem. Int. Ed. 45, 5702-5705
  Schulze, K., Mulder, A., Tinazli, A. & Tampe, R.
  
• (2006) Differential protein assembly on micropatterned surfaces with tailored molecular and surface multivalency. ChemBioChem 7, 1325-1329
  Valiokas, R., Klenkar, G., Tinazli, A., Tampe, R., Liedberg, B., & Piehler, J.
  
• (2006) Piezo dispensed density microarrays of multivalent chelating thiols for dissecting complex protein-protein interactions. Änal. Chem. 78, 3643-3650
  Klenkar G., Valiokas R., Lundstrom, I., Tinazli A., Tampe, R., Piehler J., Liedberg B.
  
• (2006) Specific and stable fluorescence labeling of histidine-tagged proteins for dissecting multi-protein complex formation. J. Äm. Chem. Soc. 128, 2365-2372
  Lata, S., Gavutis, M. & Tampe, R. & Piehler, J.
  
• (2007) Molecular printboards as a general platform for protein immobilization: a supramolecular solution to nonspecific adsorption. Ängew. Chem. Int. Ed. 46, 41044107
  Ludden, M.J.W., Mulder, A., Tampe, R., Reinhoudt, D.N. & Huskens, J.
  
• (2007) Native protein nanolithography that can write, read and erase. Nature Nanotech. 2, 220-225
  Tinazli, A., Piehler, J., Beuttler, M., Guckenberger, R. & Tampe, R.
  
• (2008) Anchoring of histidine-tagged proteins to molecular printboards: self-assembly, thermodynamic modeling and patterning. Chemistry 14, 2044-2051
  Ludden, M.J.W., Mulder, A., Schulze, K., Subramaniam, V., Tampe, R., Reinhould, D.N. & Huskens, J.
  
• (2008) Conformation of receptor adopted upon interaction with virus revealed by site-specific fluorescence quenchers and FRET-analysis. J. Am. Chem. Soc., 131, 5478-5482
  Wruss, J., Pollheimer, P.D., Meindl, I., Reichel, A., Schulze, K., Schöfberger, W., Piehler, J., Tampe, R., Blaas, D. & Gruber, H.J.
  
• (2008) Self-assembled monolayers containing terminal mono-, bis-, and tris-nitrilotriacetic acid groups: characterization and application. Langmuir 24, 49594967
  Valiokas, R., Klenkar, G., Tinazli, A., Reichel, A., Tampe, R., Piehler, J. & Liedberg, B.
  
• (2010) Chemical tags mediate the orthogonal self-assembly of DNA strands into supramolecular structures. Small 6, 1732-1735
  Mitchell, N., Ebner, A., Hinterdorfer, P. Tampe, R. & Howorka, S.
  
• (2010) In situ assembly of macromolecular complexes trigged by light. Proc. NatL Acad. Sei. U.S.A. 107, 6146-6151
  Grunwald, C., Schulze, K., Reichel, A., Weiss, V.U., Piehler, J., Wiesmüller, K.H., & Tampe, R.
  
• (2010) Native laser lithography of His-tagged proteins by uncaging of multivalent chelators. J. Am. Chem. Soc. 132, 5932-5933
  Bhagawati, M., Lata, S., Tampe, R. & Piehler, S.